23,6 Rodriguez and Eubanas: Leprosy with Antimony 579 



In only one case (Case 21) did the injection induce the phe- 

 nomenon known as lepra fever. On two occasions in this case 

 severe exacerbations of the disease occurred. Numerous small 

 nodules appeared all over the body and these ulcerated within 

 a few days, so that it seemed a^s if practically the entire integu- 

 ment was converted into an oozing sore. This patient died 

 suddenly two weeks after the end of the experimental period. 



Ulcers. — There was apparent improvement of the ulcers in six 

 cases, 25 per cent of the survivors ; in fourteen, 58 per cent, they 

 showed no change; in four, 1 per cent, they became distinctly 

 worse. 



It seems that the results with ulcers were influenced by two 

 factors besides the drug itself, namely, the duration and the type 

 of the ulceration. Table 4 gives the figures on the relation of 

 duration and improvement. 



Table A.— Relation of 1 



s- mid their improvement. 



\ Duration „,„,«,, 



Cases. Improved. 



Stationary. | Worse. 



§:;#= 



ib 





\ umber 



p -r 



Number 



Percent 





30 1 8 



27 



16 | 53 | 6 



2, 



In half of the cases that had suffered from ulcerations for from 

 one to two years improvement was noted, whereas none was 

 noted in those of over four years duration. 



As to the type of ulcer, the best results were noticed in the 

 superficial ulcerations affecting the soles of the feet. In all 

 four cases presenting this type, they were improved. Some 

 improvement was also noticed among those having infected 

 generalized lepromatous ulcers as shown in Table 5. 



Table i 



-Type of ■ 



results of 



Type of ulcer. 



„,'":,, 



s«i.,». 



w- 



,,,, 



Infected le roma 



i 



j 



• 



'! 











13 



27 











