586 The Philippine Journal of Science 1923 



Four of the ten were dropped after a month because they 

 flatly refused to continue taking the drug. They had suifered 

 nausea and weakness, even with the initial dose. At the end 

 of the period two showed some improvement in the ulcerations, 

 but the remaining four were exactly the same as before treat- 

 ment, so far as could be determined ; the leprous lesions seemed 

 in no way affected. 



CASTELLANI MIXTURE 



In connection with the trial of tartar emetic as a treatment in 

 leprosy it seemed of interest to determine whether the formula 

 proposed by Castellani for treating yaws would be of benefit in 

 leprosy. It contains not only tartar emetic, the effect of which 

 on leprosy it was desired to test particularly, but also a fairly 

 large amount of potassium iodide. This has been used variously 

 in leprosy, particularly after Danielson's advocacy of it and, 

 while it has long since been discarded as a means of treatment, 

 it is still cited as an agent for exciting a reaction that may be 

 of service in diagnosis. It was possible that in the combina- 

 tion used this effect might prove beneficial. 



Twelve General Hospital patients were put under this treat- 

 ment, most of them bedridden cases. One of these, who had 

 tuberculosis, had to be dropped after eleven doses because of 

 exacerbation of the lung lesions. There were eight males and 

 four females. Incidentally, this is the proportion existing in the 

 general population of the Culion Leper Colony, according to 

 the colony statistics. The age varied considerably; one was 

 20 years old, five were between 20 and 30, four were between 30 

 and 40, and two were between 40 and 50. The average was a 

 little over 31 years, undoubtedly considerably higher than that 

 of the total colony population. 



Three cases were classified as pure cutaneous, one as neural, 

 and the remaining eight as mixed, the commonest type among 

 well-advanced cases. In only one case was the duration less 

 than five years ; in this it was three. In five it was six to eight 

 years, in four it was ten to twelve, in one it was sixteen, and 

 in one it was thirty-two years. The average, approximately 

 eleven years, is high for the colony, but not particularly so for 

 the inmates of the General Hospital. In two cases the disease 

 was advanced, in the rest it was moderately advanced. Five 

 had no ulcers, another five of the cases had only a few, from one 

 to five in number, and in only two were they 



