22,1 Sellards and Leiva: Amoebic Dysentery 27 



January 4, 1922. Found dead; lungs normal; no lesions in bowel- total 

 emetine, 20 milligrams per kilogram within one day. 



Control for Nos. 16, 17, and 18. 



December 1, 1921. Weight, 1,700 grams. 



December 3. Enema, some mucus, no amoeba;. 



December 4. Enema, blood with active amoeba;. 



December 5. No stool. 



December 6. Enema, blood and numerous amoeba;. 



December 7. Dead; deep ulceration of lower portion of large bowel. 



PROPHYLACTIC TESTS WITH EMETINE SUBCUTANEOUSLY 



November 26, 1921. Weight, 670 grams; emetine, 10 milligrams per 

 kilogram subcutaneously; one-half hour later, amoebae injected. 



November 27. Formed stool; refuses milk; no emetine given 



November 28. Weight, 570 grams; enema, one small clot 'of blood, 

 numerous active amoebae; incubation period, two days; emetine, 5 milli- 

 grams per kilogram subcutaneously. 



November 29. Weight, 520 grams; enema, active amoeba; and blood; 

 emetine (rectally), 5 milligrams per kilogram. 



November 30. Passing mucus and fair number of amoeba;; emetine 

 (rectally), 5 milligrams per kilogram. 



December 1. Sacrificed; extensive lesions of lower part of gut; active 

 amoeba;; total emetine, 25 milligrams per kilogram within four days. 



November 26, 1921. Weight, 620 grams; emetine, 5 milligrams per 

 kilogram, subcutaneously; a half hour later, amoeba; injected. 



November 27. Enema, mucus and an occasional amoeba; incubation 

 period, one day. Emetine, 5 milligrams per kilogram, subcutaneously; 



November 28. Small blood-tinged stool, amoeba; numerous; emetine, 5 

 milligrams per kilogram, subcutaneously. 



November 29. Blood-tinged stools, active amoeba;; emetine, 5 milligrams 

 per kilogram (rectally). 



November 30. Dead; extensive pneumonia on left side; slight superficial 

 inflammation of lowermost part of bowel; total emetine, 20 milligrams 

 per kilogram within three days. 



November 26, 1921. Weight, 570 grams; emetine 

 kilogram, subcutaneously; a half hour later, amoeba; injected. 



November 27. Enema, negative; emetine, 5 milligrams per kilogram, 

 subcutaneously; vomited. 



November 28. Faacal stool; enema, negative; emetine, 5 milligrams per 

 kilogram, subcutaneously; drank milk freely. 



November 29. Enema, negative. 



December 1. Enema, a little mucus; one amoeba found; incubation pe- 

 riod, five days; very ill; chloroformed; lungs normal; rectum, moderate 

 superficial inflammation; heart-blood culture, Bacillus pyocyaneus; total 

 emetine, 15 milligrams per kilogram within two days. 



