22 r i Sellards and Leiva: Amoebic Dysentery 29 



The lethal dose of quinine for cats was not determined, but 

 in one animal under treatment the quantity was pushed until 

 toxic symptoms developed. The dihydrochloride was used as a 

 routine in 2 per cent solution. After giving the therapeutic 

 enemata the animals were held as usual with the head down- 

 ward for a half hour, but on returning them to their cages, 

 a stool was always passed promptly. Therefore, the dosages 

 recorded in the protocols represent merely the amounts injected, 

 the quantity absorbed being necessarily smaller than the re- 

 corded figures. 



March 18, 1922. Weight, 1,800 grams; injected with amoebse. 



March 21. Enema, trace of blood and a few typical entamoebas; incu- 

 bation period, three days; papaverine hydrochloride, 2 per cent solution, 

 50 milligrams per kilogram. 



March 22. Weight, 1,700 grams; fjecal stool in cage; enema, faecal 

 matter and one small blood clot; many degenerated cells resembling 

 amoeba?; one nonmotile amoeba seen; papaverine, 50 milligrams per kilo- 



March 23. Weight, 1,720 grams; passing blood and numerous amoebae; 

 quinine dihydrochloride, 2 per cent solution, 200 milligrams per kilogram. 



March 24. Enema, no blood nor mucus, one amoeba found; quinine, 200 

 milligrams per kilogram, almost completely expelled; repeated in the after- 

 March 25. Enema, negative for blood and amoebae; quinine, 100 milli- 

 grams per kilogram. 



March 26. Weight, 1,650 grams; enema, blood and mucus and nume- 

 rous active amoebae; quinine, 200 milligrams per kilogram. 



March 27. Weight, 1,650 grams; enema, negative; quinine, 200 milli- 

 grams per kilogram. 



March 28. Enema, negative for blood and amoebae; quinine, 100 milli- 

 grams per kilogram. 



March 29. Weight, 1,730 grams; enema, negative; no treatment; passed 

 formed stool. 



March 30. Weight, 1,700 grams; enema, no blood, a few amoebae; 

 quinine, 200 milligrams per kilogram. 



March 31. Enema, negative. 



April 1. Weight, 1,600 grams; passed mucus and amoebae; quinine, 200 

 milligrams per kilogram. 



April 2. Quinine, 200 milligrams per kilogram. 



April 3. Enema, a little mucus; several amoebae; quinine, 200 milligrams 

 per kilogram. 



April 4. Enema, a little mucus and, after twenty minutes' search, one 

 amoeba; quinine, 200 milligrams per kilogram. 



April 5. Enema, formed stool negative for blood and amoebae; imme- 

 diately second enema, blood and mucus and many amoebae; quinine, 200 

 milligrams per kilogram. 



April 6. Weight, 1,570 grams; enema, numerous amoebae; sacrificed; 

 deep ulcerations widely distributed throughout the large bowel; 



