The Philippine Journal of Science 



March 18, 1921. Weight, 



March 28. Enema, 

 period, ten days; papaverine, 50 milligrams per kilogram. 



March 29. Enema, a little mucus, no blood nor amoebae; papaveri 

 75 milligrams per kilogram. 



March 30. Very drowsy; enema, some blood and a few amoebae; 



Dead; lower portion of : 

 125 milligrams per kilogram within one day. 



March 18, 1921. Weight, 1,440 grams; injected with amoebae. 



March 28. Enema, formed stool, some mucus and several amoebae; incu- 

 bation period, ten days; quinine (1 per cent), 100 milligrams per kilogram. 



March 29. Formed stool in cage; enema, trace of blood and many 

 amoebae; quinine (2 per cent), 200 milligrams per kilogram. 



March 30. Enema, formed stool; no blood nor amoebae; quinine, 200 

 milligrams per kilogram. 



March 31 to April 13. Formed stools; enema, no blood nor amoebae. 



April 18. Dead; autopsy, lower portion of large bowel contains formed 

 stool; bowel wall is ulcerated and oedematous: smears show definite amoebae; 

 total quinine, not over 500 milligrams per kilogram within two days. 



June 5, 1921. Weight, 1,360 grams; injected with amoeba?. 



June 7. Enema, negative. 



June 8. Passing blood-streaked mucus rich in amoebae; incubation 

 period, three days; quinine, 200 milligrams per kilogram, in 2 per cent 

 solution. 



June 9. Enema, trace of old blood, ( 

 per kilogram. 



June 10. Enema, some tarry blood, 

 per kilogram. 



June 11. Weight, 1,320 grams; enema, negative; quinine, 200 milligrams 

 per kilogram. 



June 12. 



quinine, 200 milligrams per kilograi 



June 13. Quinine, 200 milligrams per kilogram. 



June 14. Weight, 1,280 grams; active and strong, but shows slight 

 muscular tremors and a little nystagmus; treatment discontinued. 



June 17. Enema, negative. 



June 22. Weight, 1,200 grams; enema, negative. 



June 28. Enema, negative. 



July 3. Weight, 1,150 grams; enema, negative. 



July 15. Weight, 1,150 grams; formed stool; enema, negative; observa- 

 tions discontinued; total quinine, not over 1,200 milligrams per kilogram. 



TREATMENT WITH BENZYL BENZOATE 



The toxicity of benzyl benzoate proved to be much greater 

 than we had expected. An adult cat injected per rectum with 



