34 The Philippine Journal of Science 1923 



one patient; two others remained perfectly well, but cysts of 

 Entamoeba histolytica were found in the stool of one; in the 

 fourth no symptoms have appeared, and the stool was negative 

 microscopically on two examinations. 



6. This work, taken in conjunction with previous experience, 

 suggests that Castela nicholsoni compares very favorably with 

 emetine, both in immediate and in final effects of treatment. 

 The administration of Castela can be effected very simply. 

 Neither Castela nicholsoni nor emetine, as employed at present, 

 is an ideal agent for the eradication of Entamoeba histolytica 

 infections in man. 



Case 1. — Adult Filipino. Pulmonary tuberculosis. Duration of dysen- 

 tery ten days. Symptoms started with a chill and fever, and bloody 

 mucous discharges as often as fourteen times daily accompanied by tenes- 

 mus. Temperature normal. Stools show numerous Entamoeba histolytica. 

 Inoculations in kittens produced typical dysentery (Strain II of preceding 

 section). Castela nicholsoni started, 2 cubic centimeters being given daily 

 with the evening meal for six days. After the third day of treatment, the 

 number of stools diminished to two or three daily, the blood almost disap- 

 peared, but the amoebae persisted. On the seventh day after starting 

 treatment, an examination of the stools after a saline purge showed a few 

 amoebae; the dosage of Castela was increased to 4 cubic centimeters, given 

 as before, with the evening meal. Three days later no amoebae were found 

 in the stool and treatment was discontinued. The patient remained ap- 

 parently well, but ten days after discontinuing treatment, E. histolytica 

 was again found in the faeces. Castela was given in 4 cubic centimeter 

 amounts daily for three days and the amoebae again disappeared. The 

 patient was discharged from the hospital eighteen days after treatment 

 was finally discontinued, two successive examinations of the stool after 

 saline purgation showing no amoebae. 



This patient was admitted to the hospital seven months later. He was 

 in an advanced stage of tuberculosis, and the symptoms of dysentery had 

 returned. He was put upon routine treatment of the hospital for dysen- 

 tery and responded fairly well. He died four weeks later tube] 

 evidently being an important factor in his death. The autopsy 

 tuberculosis of the lungs and intestine, and also some acute amoebic lesio 

 of the large bowel. 



Case 2.— Adult Filipino. Onset of dysentery, thirteen years ago The 

 first attack lasted about sixteen months, and there was one spvpt* t<>- 



three years ago. The 

 ago. The patient i 



began insidiously a few 

 sight bowel movements 



Large numbers of Entamoeba histolytica are present. Inoculation o* 

 kittens produced typical dysentery (Strain III). A daily dose of 5 cubic 



