36 , The Philippine Journal of Science 1923 



were easily infected. Brucea was given in 1 cubic centimeter doses twice 

 daily and caused vomiting on several occasions. During the first five days 

 of treatment the symptoms improved, and the blood gradually disappeared. 

 The amoebae became rather scarce, but never disappeared altogether. On 

 account of nausea, rectal administration of Brucea was started, giving 4 

 cubic centimeters daily, diluted with 300 cubic centimeters of water. After 

 the third day of rectal treatment, blood appeared in the stools again, the 

 amoebae were numerous, and the patient was transferred to specific treat- 

 Case 7. — Adult Filipina. Onset of dysentery, ten days ago. The stools 

 consisted of blood-streaked mucus; Entamoeba histolytica present, but in 

 small numbers. Brucea was started in 1 cubic centimeter doses, but caused 

 vomiting very regularly. Nevertheless, three days later the amoeba} dis- 

 appeared from the stools, but the dysentery continued. The coexistence of 

 bacillary dysentery was suspected, but was not confirmed bacteriologically. 

 The patient did not respond definitely to antidysenteric serum, but the 

 symptoms disappeared gradually without further specific treatment. We 

 are not inclined to attribute the disappearance of the amoebae to the mini- 

 mal amounts of Brucea that were retained. 



Case 8.— Adult Filipino. Duration of disease very u^ ct t 

 ent attack began about eleven days ago with from six to 

 mucous stools daily. Entamoeba histolytica was present in considerable 

 numbers. Inoculation of a kitten produced typical dysentery (Strain VI). 

 Treatment was started with 30 cubic centimeter quantities of a dilute prep- 

 aration of Harrisonia, given twice daily. On the second day of treat- 

 ment, the stools were free from blood, and on the third day no stools were 

 passed; on the fourth day a specimen obtained by a saline purge showed 

 no blood nor mucus, but a few motile amoeba were present. On the eighth 

 day of treatment bloody, mucous stools were passed, containing fairly 

 numerous amoebae. The Harrisonm was discontinued and benzyl benzoate 

 was substituted, giving 2 cubic centimeters of a 20 per cent solution in 

 alcohol three times daily. During the next three days the symptoms in- 

 creased in severity and amoeba persisted in large numbers. Accordingly 

 treatment was commenced with Castela nicholsoni, giving 5 cubic centi- 

 meters daily for seven days. The symptoms and amoebae disappeared 

 promptly, and the patient has not been seen since that time ppearea 



Case P.-Adult American. Duration of dysentery one and one-half years 

 with frequent remissions. Has had one short course of emetine Acute 

 exacerbation a few days ago. Entanueba histolytica was abundant in 

 stools. Kittens were infected (Strain VII). Harrisonia was given each 

 evening m 50 cubic centimeter dosage for four days. The numbed of st^ls 

 diminished somewhat and the patient felt more comfortable, but the ex 

 HnrT, bl00d ' cont ^ inin g ac *ve amoebae, continued. The dosage of 

 Harrrsoma was then changed to 20 cubic centimeters, given three timp, 

 daily. The stools showed blood and amcebaa constantly and, four davs 

 later, there was a distinct exacerbation of symptoms. The Harrisonia was 

 discontinued and specific treatment started. The quantities of H„Ji 

 given were tolerated without discomfort. Hctm&onw 



