22, i Sellards and Leiva: Amoebic Dysentery in the Cat 41 



moderate impaction of faeces. In the csecal end there was ex- 

 tensive superficial erosion of the mucosa, with a few hemorrhagic 

 areas. The entamoeba? were extremely abundant in the scrap- 

 ings from the mucosa. In the other cat, just below the ligature, 

 there was a very little fluid which contained a few amoebae; 

 otherwise, the distal portion of the bowel was very dry and it 

 was free from any lesion. The contents of the proximal portion 

 were fluid, and practically the entire mucosa of the csecal end 

 showed superficial lesions. Enormous numbers of Entamoeba 

 histolytica were present. The results of this experiment are 

 summarized in Table 1. 



Table 1. —Inoculation of amcebx per rectum and intracsecally. 





These brief experiments illustrate clearly the 

 stasis as one of the factors in determining the location of the 

 initial lesions in experimental amoebic dysentery in the cat. 

 The distribution of the lesions of amoebic dysentery in man 

 varies considerably. In long-standing fatal cases there is nat- 

 urally an opportunity for the various portions of the entire 

 large bowel to become involved. Nevertheless, there is a ten- 

 dency for the ulcerations to predominate, first of all, in the 

 caecum and ascending colon and, secondly, in the rectum and 

 sigmoid and also at the flexures. These are obviously points at 

 which stasis is likely to occur. 



During the past nine months we have on two occasions noted 

 the development of amoebic dysentery during convalesence from 

 typhoid fever. In the observation of more than two hundred 

 cases of Asiatic cholera we have not seen this complication. 



The ease with which the two adult cats were infected by intra- 

 caecal inoculation is striking. Following the injections per rec- 

 tum, four adult cats remained well and of four young cats, a 



