The Philippine 

 Journal of Science 



Vol. 22 MARCH, 1923 No. 3 



INVESTIGATIONS CONCERNING YAWS 



By Andrew Watson Sellards 

 Of the Bureau of Science, Manila 



Ernest W. Goodpasture and Walfrido de Leon 



Of the Department of Pathology and Bacteriology, College of Medicine and 



Surgery, University of the Philippines 



The following studies of yaws, of which this paper is the 

 first, are based upon experience in the treatment of the disease 

 in the Dominican Republic in the West Indies and upon investi- 

 gations conducted at Parafiaque and Las Pinas in the suburbs 

 of Manila, Philippine Islands. 



In the Dominican Republic, the major portion of the work was 

 conducted in a field camp in a rather isolated section, inhabited 

 for the most part by a somewhat primitive people. During 

 the summer of 1920, in the course of two months, approximately 

 three hundred fifty cases of yaws in the granulomatous stage 

 were treated intravenously with neosalvarsan ; these cases as 

 well as those received in the later stages have already been 

 reported. (2) Toward the close of the summer, the work was 

 extended to another district of Santo Domingo in which two 

 hundred active cases of yaws were treated by intramuscular 

 injection of neosalvarsan. 



The successful utilization of neosalvarsan under strictly field 

 conditions in Santo Domingo raised the question of the feasibility 

 of controlling or even eradicating yaws by treatment of infected 

 individuals. In order to carry out field work intelligently, it 

 seemed clear that certain preliminary investigations were 



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