220 The Philippine Journal of Science 



essential. Accordingly the study of yaws was continued, with 

 the object of giving special attention to the features bearing 

 upon the problem of its control by public-health measures. 

 Through the courtesy of the Philippine Health Service a 

 temporary dispensary was opened at Paranaque, near Manila, 

 a district the inhabitants of which have been from time imme- 

 morial constantly infected with yaws. The patients were under 

 the immediate care of Dr. Perpetuo Gutierrez, and the obser- 

 vations of clinical interest have been described by him.(l) 



There are several attractive problems in the immunology of 

 yaws. The behavior of the Wassermann reaction has not been 

 thoroughly investigated ; it is a subject of considerable interest, 

 both from a serological point of view and on account of its 

 practical importance. The reinoculation of yaws patients with 

 the virus of yaws requires further investigation. From the 

 standpoint of both the individual and the public it is very 

 important to know whether spontaneous infection that has been 

 cured by salvarsan affords any protection against reinfection. 

 The investigation of the Wassermann reaction and the behavior 

 of yaws patients upon reinoculation with yaws form the basis 

 of the second and third papers of this series. 



From the standpoint of field work, the choice of treatment 

 and the method of administering salvarsan assume aspects which 

 are very different from the conditions that obtain in standard 

 hospital practice. This subject, together with other features 

 of yaws that are of interest in the field of public health, will 

 be considered in the fourth paper of this series. 



The fifth paper deals with some problems in the histology of 

 yaws which have been cleared up by Doctor Goodpasture during 

 these investigations. 



In the last paper of this series a brief discussion is presented 

 concerning the possible control or even the eradication of yaws. 



REFERENCES 



1. Gutierrez, P. Bull. Philip. Health Service 2 (1922) 35. Arch, of Derm. 



and Syph. 6 (1922) 265. 



2. Moss, W. L., and Bigelow, G. H. Bull. Johns Hopkins Hosp. 33 



