22,3 Sellards and Goodpasture: Immunity in Yaivs 247 



profitable speculation concerning the circumstances which led 

 to their differentiation. It is clear from the preceding discus- 

 sion that the exact extent of this differentiation has not been 

 clearly determined in its biological aspects. 



SUMMARY 



1. A patient, in the well-developed secondary stage of 

 yaws, was successfully reinoculated with yaws; the lesion soon 

 regressed spontaneously. 



2. Two patients in the stage of clavos were reinoculated with 

 yaws. The lesions that developed disappeared very rapidly. 



3. The reinoculation of untreated patients suggests that a 

 long-standing infection with yaws produces a definite though 

 not complete resistance to reinfection. 



4. Four patients in the secondary stage of yaws were treated 

 with neosalvarsan and reinoculated with yaws several months 

 later. In one a typical granuloma was produced; in the other 

 three atypical reactions resulted. 



5. The results of reinoculation of patients cured with neo- 

 salvarsan indicate the development of a measurable degree of 

 active immunity in yaws. 



6. No evidence was obtained to suggest that the serum of 

 yaws cases under treatment with neosalvarsan has any curative 

 action when injected in yaws patients. 



BIBLIOGRAPHY 



1. Alston, H. Brit. Med. Journ. 1 (1911) 360 and 618. 



2. Bahr, P. H. Ann. Trop. Med. & Parasit. 8 (1915) 675. 



3. Castellani, A. Arch. f. Schiffs- u. Trop.-Hyg. 11 (1907) 19. 



4. Charlouis, M. Vierteljahresschr. f. Derm. u. Syph. 8 (1881) 431. 



5. Jeanselme und Angier. Cited in Scheube. Die Krankheiten der war- 



men Lander. Gustav Fischer, Jena (1910) 228. 



6. Levaditi, C, and Nattan-Larrier, L. Ann. Inst. Pasteur 22 (1908) 



7. Neisser, A., Baermann, C, and Halberstadter, L. Munchener med. 



Wochenschr. 53 (1906) 1337. 



8. Nicholle, H. A. A Report on Yaws in Tobago, Grenada (1894). Cited 



in Brit. Med. Journ. 2 (1901) 797. 



9. Paulet, P. Arch. gen. med. 17 (1848) 385. Cited in Brit. Med. Journ. 



2 (1901) 797. 

 10. Rost, G. Munchener med. Wochenschr. 58 (1911) H36. 



