258 The Philippine Journal of Science 1923 



the main stock of neosalvarsan was obtained in 3-gram ampules ; 

 and, here again, with the various delays incident to injection, 

 it was often impossible to complete the injection of the entire 

 quantity of solution within thirty minutes after its prepara- 

 tion; occasionally as much as forty-five minutes was required. 

 Also, since no ice was available, the solution was always 

 prepared with water at summer temperature. No control 

 could be exercised over the diet or the preliminary catharsis 

 of the patients. In view of these drawbacks, doses slightly 

 smaller than the standard were employed. The scheme of 

 Bergen (3) was modified as shown in Table 1. 





Table 1. — Dosage of neosalvarsai 











Bergen. 



SUSS 



Age. 



Dose. 



Age. 



z 





Yrs. 



| 



Yrs. 



Subadults ... . 





ill 











InfMt8 



This table is intended, of course, only as a general guide for 

 the various ages or, in many instances, for the apparent or 

 the probable age. Obviously, the dosage must occasionally be 

 reduced, or treatment deferred altogether in patients showing 

 marked emaciation, outspoken pulmonary or cardiac disease, 

 and also in febrile conditions other than those due to yaws. 

 The infrequency of arteriosclerosis and renal insufficiency in 

 the Tropics eliminates any necessity for routine examination 

 of the urine. 



Other methods of treatment have been recommended, more 

 especially for avoiding the use of injections under unfavorable 

 conditions. Castellani's formula (5) containing potassium iodide 

 and tartar emetic has met with considerable favor; however, 

 this treatment must be continued daily for approximately one 

 month. An adult, or a child over 14 years, must take 300 

 grams or more of potassium iodide. The cost of this item 

 alone is rather more than 4 pesos as contrasted with 1.8 grams 

 of neosalvarsan at about 0.80 peso. 



