272 r ^ e Philippine Journal of Science 1923 



In proportion to the degree of acute inflammation present, few 

 treponemata were found. The organisms are most numerous 

 within and about the haemorrhages in the epidermis. 



Yaw 2. — On September 2, this man received 0.75 gram of 

 neosalvarsan intravenously; a rise in temperature and intense 

 pain over the body followed. 



September 5, three days after treatment, the lesions showed 

 a distinct change. They were dry on the surface and showed a 

 bright pink, healthy color instead of the yellow seropurulent dis- 

 charge previous to treatment. There appeared to be a thin, 

 unpigmented, transparent film of epithelium covering the pap- 

 illary crests disclosing the bright color of the circulating blood 

 beneath, and in the center a soft thin crust. The surface was 

 otherwise clean, no pus to be seen. Under local anaesthesia 

 Doctor Franco removed a small yaw, measuring 0.8 centimeter 

 in diameter. Sections 1 millimeter thick were immediately fixed 

 in 10 per cent formalin and in Zenker's fluid. 



In gross the cut surface is gray and semitranslucent without 

 the yellow tint of pus or the appearance of haemorrhage. There 

 is obviously less fluid exudate. 



Microscopically there is very great change, most marked in 

 the epidermis. On the surface is a thin layer of leucocytes and 

 desquamated epithelium with beginning cornification. The 

 evidences of exudation have almost completely disappeared ; only 

 a few straggling leucocytes caught in intercellular spaces re- 

 main in the site of previously great activity. The still deeply 

 penetrating and interlacing columns of epithelium are compact 

 and sharply outlined. Mitotic figures are numerous and though 

 the cells, even of the basal layer, are larger than normal there 

 is no appreciable excess of intercellular fluid. Large, branching 

 pigment strands, while relatively sparse, are more numerous 

 than in the previous section. 



The papillae of the corium present more evidence of the pre- 

 vious inflammation. Many of these are still greatly enlarged 

 and turgid with fluid exudate. The interstices between collagen 

 fibrils are filled with a clear, pink-staining, gelatinous material, 

 like thick serum, within which are vacuoles. The blood vessels 

 are not noticeably dilated, but the lymphatics are remarkably so. 

 These areas contain relatively few cells ; the majority are plasma 

 cells and polymorphonuclears. There are appreciably more 

 hyalinized plasma cells than were observed in the section before 

 treatment. 



