576 



The Philippine Journal of Science 



These animals were employed in an experiment having for 

 its object the determination of the relative resistance of native 

 dogs to strychnine and, consequently, was in a sense supple- 

 mental to the first experiment. The minimum dose which had 

 proved fatal in the first experiment was injected subcutaneously 

 in all the dogs. To those that did not succumb to this amount, 

 and after the acute symptoms had subsided, an additional 

 amount of strychnine equal to the difference between the next 

 fatal dose (determined as before) and the one injected was 

 administered. This procedure of administering additional 

 strychnine sufficient to equal the next succeeding lethal dose 

 was repeated until all the animals finally died. The results 

 obtained are given in Table 7. 



Table 7. — Dogs receiving fatal doses of stry chine sulphate by subcuta- 



Dog No. 



w„*. 



«. 



■ssr 





■sir— 



S- 



„,, 



18 



"2: 



E 



2 



T 2V> 



7* 



"-■ 



-• 



H 









«" 









»-- - 









5 



11 



"« 



~-i» 



















Table 8. — Summary 



of data 



t« TafeZe 



7 - 



,„*«,».. 









IMi»{ "S- 



2Sf 





Dokb died. 



<-\ - 



„. 



Ts5 





12.5 



IZ\ In 





0.X 



DISCUSSION OF RESULTS 



It will be noted from the experimental results obtained that 

 the animals were uniformly slower in showing the early effect 

 of the drug, namely, hyperexcitability, than were those experi- 

 mented upon by Sollmann.(i2) On the other hand, three of 

 them were killed by rather smaller doses. For purposes of com- 



