On the identity of Sanguinarine and Chelerithrine. 221 
Of the pure substance dried at 105° C., 
0-356 grammes burned with oxyd of copper and oxygen, fur- 
nished 0-918 carbonic acid = 70°34 per et. of carbon and 0-167 
water = 5°21 per ct. of hydrogen. 
The direct determination of nitrogen gave 5-07 
03925 gramm. of the double salt of the fa dedehloraee of chele- 
rithrine and chlorid_of platinum yielded 0-707 of platinum: thence 
the atomic weight = 341:74. 
Accordingly the composition of Chelerithrine is: 
70 
Carbon, - - - ‘34 
Hydrogen, - - - - 5-21 
Nitrogen, - - - . 5-07 
Oxygen, - - - 19-38 
' 00-00 
_ The composition of Sanguinarine I found :* 
Carbon, 70:03 69°82 70:02 
Hydrogen, 5:27 5°08 5:14 
Nitrogen, 5-23 
Oxygen, 19°14 
100-00 
The atomic weight was found in three determinations 32277 ; 
362°7 ; 346-4, or taking the mean =343°9. 
From all this it appears that Chelerithrine and Sanguinarine are 
one and the same substance sie area to the formula Css 
HieNOs, This formula e! ives 
Carbon, - - - 70-80 
Hydrogen, - - - 4:97 
Nitrogen, - . - . 4:35 
Oxygen, - - - - 19-88 
- 100-00 
It will be perceived that the above formula inéludes one equiva- 
lent of carbon more than the one I formerly deduced from the _ 
analysis of Sanguinarine. 
or the preparation of one or the other of these alcaloids the 
féllowing method is the simplest and cheapest. 
Digest the root of the plant Sanguinaria Canadensis (or Cheli- 
donium majus) with water strongly acidulated with sulphuric = 
and precipitate with ammonia, wash and dry the precipitate, 
solve in ether, and treat with animal charcoal. After filtration iii 
alealoid is precipitated with a solution of pure sulphuric acid in 
ether. Itis pure sulphate of sanguinarine. 
* Annalen d. Chemie und Pharmacie by Liebig and Wohler, B. xu, p. 233. 
