TRANSACTIONS OF THE SECTIONS. 85 



(B) From bromocodide : probably at first a lower homologue broinomorpbide 

 (not yet isolated), converted subsec[iiently into hromotetramorphia and deoxy~ 

 morphia by the reaction. 



Broniomorpliide. Deoxy morphia. Bromotetramorpbia. 



5Cj, H-, BrNO,. + 411, = 4IIBr + G,, Hj, NO, + C„, H,, BrN, Oi,. 



(C) From deoxycodeia : only blackened tarry substances, not fit for analysis ; 

 hence probably the deoxymorphia got in B is not formed from deoxycodeia "pre- 

 Yiously produced. 



Deoxymorphia and bromotetramorphia much resemble in all their properties 

 their homologues deoxycodeia and bromotetracodeia ; the first gives crystalline 

 salts, the second amorphous ones. 



The constitutions of all the above have been verified by analyses of the hydro- 

 bromates, hydrochlorates, platinum salts, &c. In qualitative reactions, the deoxy- 

 salts are identical with apomorphia salts. 



On treating bromotetracodeia and bromotetramorphia with excess of cold strong 

 hydrochloric acid, dissolving in water, and fractionally precipitating by strong 

 liydi-ochloric acid, the bromine in these bases becomes replaced iDy chlorine, 

 yielding the following bodies, that much resemble in all their properties the cor- 

 responding brominated salts : — 



Chlorotetracodeia hydrochlorate C^, ^^3 CI Nj O;,, 4HC1 

 Chlorotetramorphia hydrochlorate C^^ H^, CI N^ Ojj, 4HC1. 



By digesting codeia for six hours at 100° with hydrobromic acid, there was 

 obtained a substance that ga'^e numbers (after treatment with hydrochloric acid) 

 intermediate between those required for the two last-named bodies. This may 

 have been only a mixture of these two ; but it seems very probable that a series of 

 products should exist intermediate between these extremes, viz, — 



Cgg H— BrN^ 0,2 = Bromotetramorphia 



C,,l4BrN,0,: 



C,„H„BrN,0,, 



C,JI,,BrN,0, 



0^2 Hg3 BrN^ 0,2 = Bromotetracodeia 



Cgs H-3 CIN, 0,, = Chlorotetramoi'phia 



c,3h;,cin,o;2 



C^„H^„ Clls, Oj2 = Chlorodicodeia-dimorpliia 



C,,H,,C1N,0,2 



C72 H^3 CIN^ Oj2 = Chlorotetracodeia. 



Assuming that this substance was not a mixture, it might be termed chloro- 

 dicodeia-dimorpliia. 



Dr. Michael Foster finds that the tetracodeia and tetramorphia compounds 

 produce in adult cats a great excitement of the nervous svstem, and apparently 

 paralyze the inhibitory fibres of the pneumogastric. Apparently the morphia 

 compounds are somewhat more potent than the codeia bodies in this case. 



Deoxycodeia and deoxymorphia salts produce in adult cats convulsions more 

 epileptic in character than tetanic. No trace of emetic symptoins has been observed 

 with any of the salts of this class of bases, which in physiological efi'ect, as 

 well as chemical reactions, are almost indistinguishable the one from the other. 



This absence of emetic symptoms conclusivelj' proves that apomorpliia is not 

 among the products of the action of hydrobromic acid on codeia. From its known 

 production from this base by tlie action of hydrochloric acid, as well as from the 

 analytical numbers obtained, the formation of apomorphia has been previously 

 looked upon as probable. 



By the action of hydriodic acid containing 55 per cent. Ill on codeia in presence 

 of phosphorus, a series of substances have been formed that present the composi- 

 tions included in one or other of the two general formulfe, 



4X -I- hTII + pll, 0, 

 4Y + HHI+^jn;0, 



