86 : REPORT—1863. 
whole of the eye could be touched with perfect impunity without winking. 
Two days after this most of these effects had disappeared, a previously 
hageard look had gone, and he felt all right again. Four days later he was 
perfectly well. He had taken altogether seven drachms of the salt. 
Exp. 4.Male, aged 42, health good. For three weeks the salt was given in 
doses of from four to eight grains thrice a day, which diminished the sensi- 
bility of the fauces. In the next two days half-drachm doses were given 
thrice a day; and as insensibility was not complete, a scruple was given 
every three hours for two days more. The result of this was complete 
angsthesia, so that bodies could be introduced into the larynx; but, as in 
the previous experiment, when coming into contact with the epiglottis, they 
had to be withdrawn from the excitation of reflex action. In from five to 
seven days sensation was quite regained, and all the functions restored with- 
out any inconvenience. 
Exp.5.—Male, aged 51, health good, excepting a laryngeal voice. For fifteen 
days he was given at first 24 and then 5 grains of the salt twice a day, with 
no noticeable effect beyond improving the appetite, voice, and complexion. 
He was then given twenty grains of the bromide four times a day for four 
days ; and on the morning of the fifth day there was anesthesia of the fauces, 
hose, mouth, and tongue; and all the special senses were somewhat affected. 
The stomach likewise, for he had no desire for food, although feeling well 
in health ; and he had little or no sensation in micturition. The countenance 
was paler than usual, the skin very clear, and the tongue clean. Differing 
from previous cases, the epiglottis was almost completely insensible, and but 
feebly influenced by the contact of instruments passed into the trachea. 
Next day he felt a little giddy and stupid; but in the three following days 
the senses of taste and smell were returning, appetite indifferent, tongue 
much furred, intestinal and renal secretions regular and normal in quantity, 
and sensation restored to the urethra. 
Fight days later he was sleepless, and had no desire for food nor for sleep ; 
a bitter taste was present in the mouth, with an odour of ptyalism; the 
prime vie were disordered: throat was now sensitive. In a few days all 
these symptoms disappeared; but it must be stated that they were partly 
due to an attack of cold from which he was then suffering. 
Exp. 6.—As in the first experiment, half a drachm of the salt was given 
to & man aged 35, in good health, every two hours, using chiefly a tea and 
bread diet: During the first day he took four drachms, the second the same 
quaiitity, and the third a similar quantity, when it had to be stopped. The 
syifiptoms the first day were very mich like those in Exp.1; on the 
second there was some giddiness and stupor, with impairment of sensation 
both in the skin and mucous membrane, but not amounting to complete 
anesthesia; on the third day he had passed a restless night, and towards 
evening he was like a man intoxicated; he felt light-headed and drowsy ; 
speech, hearing, and sight were materially affected ; he had no sense of smell 
not taste, nor any sensation in the mucous membrane of the throat, nose, 
ears, eyelids, and alimentary canal. Pressure was scarcely felt over the 
stofiach ahd bowels; there was no sensation in the urethra, and but little in 
the rectum; and the bladder would have been distended if he had not been 
requested to empty it; its contractile power was unimpaired. The sensibility 
of the skin was blunted, but not gone. 
General atiesthesia of the entire mucous tract, moré or less, had beet 
here produced, and it was deemed prudent not to catry out the administra-= 
tion of the salt further; the pulse was slow and regular, and forty-four per 
