88 REPORT—1863. 
Exp. 12,.—The same quantity was given three times a day to a man of 35, 
and persisted in for five weeks. At the end of that time he had anorexia 
and chronic anesthesia of the throat, 7. e. impaired sensibility, which had 
been present for ten days. It was also diminished in the conjunctive and 
nostrils; rhinoscopy was very easy. 
Exp.13.—Thirty grains were given to a woman twice a day for a fort- 
night, and the symptoms produced were not unlike those in the previous 
experiment. 
Exp. 14,—A similar quantity, three times a day, was given to a young 
man of 26. He took it well for six days, when it had to be stopped, for he 
felt light-headed and queer, with some restlessness of the limbs. The 
mucous membrane of the fauces was feebly sensible, and could be freely 
touched without any inconvenience or resistance. 
Exp. 15.—In another person, thirty grains given three times a day for ten 
days produced no decided change whatever beyond altering the complexion. 
Exp. 16.—Half a drachm was injected into the rectum of a male aged 31 
every four hours for two days. It was readily detected in the urine, and 
exerted its influence chiefly in diminishing sensation in the genito-urinary 
tract of mucous membrane and lower part of the alimentary canal, which 
felt benumbed. It seemed also as if sensation was diminished in the fauces. 
Exp. 17.—The same experiment, repeated upon another man, caused a 
slight attack of diarrhcea, but sensation was nevertheless sensibly impaired. 
Exp. 18.—A scruple in half an ounce of water was injected into the male 
bladder, and repeated twice at intervals of two hours. It was quickly ab- 
sorbed, for reagents indicated the presence of but a small quantity in the 
urine voided before each recurrence of the injection. Very slight anesthesia 
was experienced at the neck of the bladder; and in seven hours from the 
first injection there was copious diuresis. 
Exp. 19.—An eight-ounce mixture, containing half a drachm of each of 
the iodide and bromide of ammonium, was ordered in tablespoonful-doses 
twice a day to a healthy female aged 22. The first dose caused severe sickness 
and vomiting, with great prostration and syncope; severe abdominal pain, 
but no diarrhea. She remained very poorly the remainder of the day. 
Exp. 20.—A similar mixture, containing a drachm each of the two salts, 
was ordered for a female aged 28, with aphonia—on the same day as in the 
preceding experiment. The first dose was swallowed at the chemist’s, and on 
her way home she was seized with sickness and vomiting, great pain in the 
bowels, prostration and diarrhoea. Next day she was well again. 
Although the symptoms were the same in each experiment, excepting the 
presence in one and absence in the other of diarrhcea, yet they clearly 
proved that the salts of iodine and bromine are incompatible. I did not 
like to repeat the experiment. In Exp. 19 the quantity of each salt taken 
was about two grains, whilst in Exp. 20 it was about four grains, The 
general symptoms were certainly seyerer in the latter, which may account 
for the presence of the diarrhcea. 
I have performed several experiments upon animals with bromide of am- 
monium, and have given various quantities by the stomach, with compara- 
tively no inconvenience, and they rather go to prove that tolerably large 
doses may be given even to very young children without any ill effect ; in- 
deed I have administered pretty large doses to infants and children for 
hooping-cough and other diseases, with the most satisfactory results. 
I have not injected solutions of the salt into the circulation in animals, for 
the reason that no valuable or practicable inferences would have been fur- 
. 
