4 
PHYSIOLOGICAL EFFECTS OF THE BROMIDE OF AMMONIUM. 91 
nate. Five grains bromide administered twice a day, and his diet regulated. 
No change for the first fortnight; in third week 3 lbs. were lost, and then 
the diminution went on pretty regularly for about four months, averaging 
about a pound a week; atthis time he weighed 208 lbs. The bro- 
mide was giveh in ten-grain doses every morning before breakfast for six 
weeks, and the decrease in that period was 11 pounds; it now caused a little 
nausea, and was intermitted for a short time, and yet diminution still went 
on, and the health became very good. It was resumed in four-grain doses in 
the morning, and after the lapse of ten months from the commencement he 
had lost 53 pounds; which brought him, he said, to something like his normal 
standard. He has latterly been taking the effervescihg bromide, which he 
finds exceedingly grateful to the stomach, but with no very sensible diminu- 
tion in his weight now. All the other symptoms improved, asin Exp. 21. 
This person had previously given a long trial to the Fucus vesiculosus, until 
“his vitals turned against it,’’ and without the slightest benefit. 
Exp. 23.—Major J., aged 44, very corpulent, with reddish face and stout 
limbs. Palpitation of the heart and feeling of fulness in the chest, very fond 
of puddings and port wine, which he said he digested well. Weight 198 lbs., 
which was uncomfortable, as he was a short man. Hight grains of bromide 
given twice a day: the puddings were stopped and the port wine changed. In 
five months there was a loss of 23 1bs., and in another three months 83 lbs. 
more, so that he was reduced to 1663 lbs. 
Exp. 24.—Mrs. St ——, aged 47, moderately stout, but with all the expres- 
sion of great deposit of atheroma and cholesterine in the vessels. Weight 
182 lbs. The bromide was given in the mornings before breakfast only, in 
doses of six grains. One of the first effects noticed was the subsidence of a 
most irritable temper, and improvement in the facial expression ; this was 
followed by slow and giadual loss of weight, until in five months she was 
reduced to 163 lbs. The diet was regulated here as well. 
Exp. 25.—Rev. P. J., aged 64, getting so stout that it was a cofistant source 
of discomfort; weight 213 lbs. The bromide was given pretty regularly, at 
first in small doses, then in larger, without any appreciable benefit. An effort 
was at the same time made to regulate the diet, but great difficulty was ex- 
perienced in effecting this. The diminution therefore was comparatively slight, 
more especially as milk was freely indulged in. 
Exp. 26.—Mary P ; aged 36, inclined to be stout, with a large flabby 
heart, and from the facial expression and general appearance, the subject 
most probably of disease of the large blood-vessels at the heart and base of 
the brain, taken together with a family history which seemed strongly to 
confirm it: Weight 162 lbs. The bromide here was most invaluable, for a 
marked improvement followed, atid the weight was fediti¢ed sétisibly and 
comfortably; although not more than 11 Ibs. 
Hep. 27.—Tulia D.; aged 28, with the atheromatous expression, slight 
dyspnea, fair embonpoint, good digestion and exeéllent health, Three-grain 
doses of the bromide twice a day, taken for many weeks, most sensibly acted 
on the first three, aiid she became a little thinner; Which was shown by the 
general loosening of her garments. 
Expts. 28, 29,30.—Three males, aged 27, 32; aid 41, who were moderately 
stout, and in whoni from 7 to 14 lbs: Were reduced in Weight by five grains of 
the bromide twice a day for seven months. 
Expis; 31 and 32.—Two females, aged 39 and 43, also moderately stout, 
Whose weight Was likewise diminished in the same ratio, by a similar quan= 
tity Of the salt takeii for six months. 
