194. REPORT—1868. 
Datron*,.—Dr. Dalton of New York attempted to ascertain the amount of 
bile which passed into the duodenum from the choledic duct by means of a 
duodenal fistula. But as in this manner it is obviously impossible to deter- 
mine the amount of the entire quantity given off by the liver, no account of 
his researches need be given. 
Fuinr+.—The last experimenter we need cite is Dr. Flint of New York. 
As his object, however, was rather to ascertain the amount of cholesterine 
secreted by the liver, than to determine the quantity of biliary secretion, he 
does not give us much information on this point. In one dog the bile was 
collected for thirty minutes at a time during various periods of the day, and 
was found to be secreted at its maximum four hours, and at its minimum 
twenty hours, after feeding. The dog weighed 10 pounds; and there were 
collected, in the twenty-four hours, 243-233 grains—an amount which gives 
an index of the quantity secreted during that period. He further says that, 
disregarding slight variations, which might be accidental, it may be stated in 
general terms that the maximum flow of bile from the liver is from the 
second to the eighth hour after feeding, during which period of time it is 
about stationary. 
We here subjoin a Table containing the results of the experiments of 
different physiologists who have investigated the subject of the biliary secre- 
tion. With the exception of the results of those of Dr, Flint and Dr. Scott, 
the Table, of which the arrangement is slightly changed, is taken from 
Canstatt’s Jahresbericht for the year 1863, No. 1. p. 141, The weight is 
given in grammes. 
Amount of bile se- Quantity of bile 
ereted in 24 hours secreted in 24 hours 
per kilogramme |Food taken in 24 hours) for 100 grammes 
Names of obseryers.| weight of dog. j|per a re weight of food. 
_———<——_——— of dog. 
Fresh Dry Fresh Dry 
bile. | residue. bile. | residue. 
Nasse, 1851 ... 19:2 0-685 {155 flesh 123 0-440 
22:8 0:700 208 ,, 111 0°337 
23:1 0:784 |260 ,, 8-9 0:300 
240 0-765 |At will ue ree 
28°4 0°760 3 ans ee 
Ubeze 0-446 100 flesh and 100 br. hic oa 
179 0-400 (180. ,, 100 ,, od is 
12:2 0:500 87 bread 139 0575 
Bidder and Schmidt,) 15-9 0840 |32°4 flesh, 1-7 fat 49°35 2608 
1852. 16:7 0-696 |178 ,, 78 milk 83'5 3°48 
24-5 1:176. |79'5 ,, 8&3 bread ray 1:23 
28°7 1268 (664 ,, 85) ,, 35:1 1:54 
Arnold, 1854-57 116 0373 |96 fiesh 12:0 0885 
81 0:215 |\60 bread 13-4 | 03857 
Kélliker and Miller, 327 1:0384 or ae 
1853. 326 1:280 |98 flesh oa Be 
2671 1:013 (92 ,, 28°56 1694 
21:5 0-748 /94 ,, 22°85 0792 
86'1 1162 (64 ,, 56°50 1-816 
53°6 1683 |94 ,, 56-7 179 
32°1 ann 37-9 bread, 90 cubic ve aA 
| centimetres of milk ete nae 
Scott, 1858 (dese: 23:11 1:128 /58°7 flesh, 10°3 milk 35:0 16 
Flint L862). .seses: be EOS 0-440 Pr ee eG 
* Physiology, p. 190, 3rd edit. 
+ American Journal of Medical Sciences, vol. xliv. p. 386. 
