ON THE ACTION OF MERCURY ON THE BILIARY SECRETION. 203 
dog B, the mucous membrane of the large intestine was streaked with bright 
red lines running longitudinally throughout its entire length. 
In all the dogs, except dog D, there was unusual vascularity of the pan- 
creas, but in none was there any abnormal appearance of the salivary glands. 
In no case did the liver present any unusual appearance. 
These facts show that on the dog mercury has the same action as it exerts 
on man. 
Resvits oF THE HXPpERIMENTS MADE ON Dogs witH BrrrAry Fistunm to 
DETERMINE THE ACTION OF Murrcury As A CHOLAGOGUE. 
During the two years over which the Committee’s inquiries extended, forty- 
one dogs were subjected to the operation for establishing a biliary fistula. 
Of these, four died during its performance from the effects of chloroform. In 
four others the operation was not proceeded with after opening the peritoneum, 
in consequence of the impossibility of bringing the fundus of the gall-bladder 
in contact with the abdominal wall. The operation was completed in thirty- 
three cases, but from various causes, which the Committee consider it unne- 
cessary to detail minutely, satisfactory observations could only be carried on 
in nine dogs. These have been numbered consecutively from one to nine, but 
it has been thought better to arrange the numerous observations made upon 
them according to the preparation of mercury employed. 
Observations with Pil. Hydrargyrt. 
The first dog’ (No. 1) in which a biliary fistula was successfully established 
by the Committee was a healthy retriever about eighteen months old, weighing 
18°5 kilogrammes, for which we are indebted to Mr. Nunneley of Leeds. The 
operation was performed on the 29th of May, 1867. The wound in the 
abdominal wall healed rapidly. Shortly after the operation the faeces became 
clay-coloured. The general health of the animal was excellent when on the 
10th of June the apparatus for collecting the bile was applied, and the obser- 
yations recorded in the following Table (Table II.) were commenced. 
As the metrical system of weights is used in all the Tables with regard to 
everything except the doses of drugs, it may be of service to remind the 
English reader that— 
1 gramme= 15-434 grains, 28°34 grammes =1 ounce, 1 kilogramme = 2°2 
pounds. 
Tasix II.—First Series of Observations on Dog 1. Daily amount of 
Bile secreted without Mercury. 
1 2 3 4 5 6 
| For each 100 
Weight x * Quantity of bile For each kilo- 
of Amount of food, in secreted in 24 gramme of dog there caBthice of dey 
|| dog BESmunes: hours were secreted S000; Aner ce 
Date. ee . secreted 
ico T .*, | . . . . . . . . 
1K: . Fluid} Bile | Bile || Fluid| Bile | Bile || Fluid} Bile | Bile 
‘Kilogs. | Water. |Milk. Bread.) Meat.) 16. |solids,| salts. || bile. |solids.| salts. || bile. |solids.| salts. 
} \| —- - ||——|--—— 
1867. || grms.|grms.| grm. ||grms.| grm. | grm. |/grms.| grms. | grm. 
Junell.|| 18°5 || None. | 567 | 170°1 | 283°5 || 150°4 | 8°843 | 1:221|| 8°12 | 0478} 0°066)) 65°5 | 3°85 | 0°53 
» 12. ” ” ” ” 125°0 | 8-400 | 1:355 
» 1.| Frese - rs is 757 | 5:791 | 0°836|| 4-09 | 0°313] 0-045 |} 32:9 | 2:52 | 0:36 
% 21.| 1 gs » ” ei 121°8 | 6°954 | 1:280 
3 18.]| te cos ” ” » 115:0 | 7-290 | 1°345 
» 1. ” ” » »» || 130-7 | 8-456 | 1520 
DON GaN  rrisibevvesachuas-eacwusunresydyattd-dedsvacatuatange 119°76} 7°622 | 1°259|} 647 | 0-412 0-068 | 52°18 | 3°32 | 0°548 
Nove.—The amount of dry food consumed daily during the above period amounted to 22°5 grammes. 
” » = for each kilogramme of dog amounted to 12°3 grammes. 
