ON THE ACTION OF MERCURY ON THE BILIARY SECRETION. 207 
Pil. Hydrargyri was again given. Extraordinary variations occurred in 
the amount of bile obtained during its exhibition, and the quantities appear 
to show that the secretion of bile was diminished; but they are in truth ren- 
dered valueless by the circumstance that a considerable quantity of bile was 
separated by the kidneys, owing, most probably, to its free exit by the fistula 
having been interfered with. The animal was never purged until July 30th, 
when it twice passed a considerable quantity of liquid feces. Although it 
did not lose weight to any notable extent during the period embraced by 
Table V., its strength diminished. In order that the dog might rally, the 
observations were suspended, and a more liberal diet allowed. It grew gra- 
dually weaker, however, and died on the 5th of August. On dissection a 
layer of recent lymph was found over the whole surface of the peritoneum. 
The cause of the peritonitis was not evident *. 
Obsérvations with Calomel. 
The second dog (No. 2), with a biliary fistula, was a full-grown half-bred 
collie, weighing 15-6 kilogrammes. The operation was performed on the 5th 
of September, 1867, The wound healed perfectly, and collection of the bile 
was begun on the 20th of September. ‘The general health of the animal 
was, however, indifferent ; its appetite was uncertain, and its general strength 
feeble. When the apparatus was applied, the animal appeared to be much 
distressed by its weight, and by the constriction of the thorax and abdo- 
men, which its proper application rendered necessary. After the operation 
the fseces became clay-coloured. - 
During seven days, from September 21st to 27th inclusive, observations 
- were made with a view to determine the normal secretion of bile: the results 
are given in the following Table (Table VI.) :— 
Tante VI.—First Series of Observations on Dog 2. Daily amount of Bile 
secreted without Mercury. 
1 2 3 4 5 6 
For each 100 
Weight p Quantity of bile For each kilo- 
oO Amount of food, in secreted in 24 _|/gramme of dog there Pred ther ae Say 
a grammes, ° (pater arciearerad ood there were 
Date. 4) a secreted 
A || Fluid | Bile | Bile || Fluid} Bile | Bile Fluid| Bile | Bile 
Kaloge.|| Water. Milk.| Bread.| Meat. bile. |solids.| salts. |} bile. |solids.} salts. || bile. |solids.) salts. 
1867. germs. | grms.| grm. || grms,| grm. | grm. | orms, grms, | grms. 
Sept. 21./| 15:6 |} None. |56£ | None. | None.|/13 7:29 | L41 || 8333 | 0°467] 0°09 || 230°0 | 12°9 | 2°51 
eels » [564 2 » ||.81 | 4:48 | 0°907]| 
he ecura tely nojted. | 
tate) ment in book} is barat hie es Pe 
ann ae =p scar cely lany foo|d ta- 94°15 | 6072} 1:205 
zen.” 
| (24 None. |225°6| None. |None.|| 94°70) 5°750} 1:01 
9 15°6 ” 282 Pn 3102 || 78°80} 5°92 | 1:25 73°9| 560] 118 
ors ” 197-4 2 225 62°50| 5:70 | 1:08 | 
iiss Has onlly takjena litt!lemilk|/ 35°50 | 1°99 | 0-436 || 227 | 0°12 0:027 
Mean for seven days ....ss.csscsssscsssestesseeeeeees || sa-s6| 531 | 1-042 || 527 | 0-34 | 0-066] | 
Nore.—On the 25th September the dry food consumed amounted to 1057 grammes, or 67 grms, per 
kilog. of dog; on the 21st, 56°4 grms., or 3°6 grms. per kilog. of dog. 
In this Table, as well as in several others, it will be observed that the 
amount of bile collected was greater on the first than on other days—a rule, 
however, by no means invariable. The occurrence was probably due to the 
canula having permitted a freer exit to the bile than the fistulous opening 
* For further observations on the action of Pil. Hydrargyri see Tables TX. and X, 
