208 REPORT—-1868. 
which the contraction of the recti abdominis always tended to close. At 
first, therefore, after the introduction of the canula, a large quantity of bile 
pent up in the ducts may have escaped, or the larger quantity may have been 
due to increased biliary secretion. 
The average quantity of bile secreted daily by dog 2 during the seven 
days embraced by Table VI. was of fluid bile 82-46 grammes, of bile solids 
5°31 grammes, of bile salts 1-042 gramme. During the whole period the 
animal took a very variable quantity of food; on two days the amount was 
not accurately recorded; the average quantity of dry food consumed daily 
could not therefore be estimated. The biliary secretion was, when com- 
pared with the amount of food, extremely variable, however, as column 6 of 
the Table suffices to show. 
The general health of the animal had not materially suffered by the con- 
tinued application of the apparatus, although at at first occasioned so much 
distress. 
It was now decided to observe the effects of calomel. Table VII. (p. 209) 
gives the results. 
During the six days embraced by Table VIIL. calomel was given in- 
ternally in varying doses. The effect of the medicine upon the general 
health of the anjmal was very decided ; it grew daily weaker and thinner, it 
lost its appetite, had attacks of vomiting on October 2nd and 3rd, and died 
on October 5th, apparently from inanition. Purgation, foetor of the breath, 
or ulceration of the gums were never produced by the drug, nor was there 
any evidence’of salivation. 
On October 2nd the bile was lost, and on the 8rd, two days before the 
death of the animal, and when it took no food, only 2-2 grammes of bile 
were secreted. An average has been taken from the first four days during 
which the animal took food. The average quantity of fluid bile secreted 
during these four days was 60:02 grammes. 
The average quantities of bile solids and salts have not been estimated 
seeing that they were not ascertained on September 29th. The Table shows 
that under the action of the calomel less bile was secreted than there was 
previous to its exhibition ; but as the amount of calomel given had seriously, 
indeed fatally, injured the health of the animal, it was determined to try in 
the next case the effect of minute and frequently repeated doses. 
Dog 3 was a young healthy retriever, weighing 12-9 kilogrammes. The 
operation for biliary fistula was performed on the 13th of October, 1867. A 
few hours afterwards the dog pulled the india-rubber tube out of the fistula, 
and the external opening of the fistula closed, so that on October 15th the 
fistulous opening had to be reestablished by an incision. The wound in 
the abdominal wall healed satisfactorily, the feces were clay-coloured, and 
the animal was in excellent health when the collection of bile was begun, 
October, 26th 1867. It was decided to observe the effects of very small 
doses of calomel (7, of a grain) frequently repeated. The bile was col- 
lected on four successive days previous to, and on four consecutive days 
during the exhibition of the drug without any break between the two series. 
Table VIII., p. 209, gives the results of both series of observations. 
During the four days previous to the administration of the calomel the 
animal secreted daily on an ayerage 70°62 grammes of fluid bile, 3-792 
grammes of bile solids, and 0-83 gramme of bile salts. The health of the 
inimal during these days was excellent. 
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