218 REPORT—1868. 
Dog 7 was a strong full-grown retriever, weighing 27-4 kilogrammes, 
for which we were indebted to Dr. Kelburne King, of Hull. The operation 
for biliary fistula was performed on the 24th of April, 1868. The healing 
of the wound around the fistula was so slow that observations could not be 
begun before the 29th of May. Table XII. p. 215, gives the results pre- 
vious to the administration of corrosive sublimate. 
During the five days embraced by Table XII., the amount of food 
consumed was constant. On May 31st the bile was unfortunately lost, 
owing to the apparatus having slipped. The average quantity secreted 
during the remaining four days was of fluid bile 127-15 grammes, of bile 
solids 6:43 grammes, of bile salts 1:03 gramme. The observations were 
interrupted on accoant of repairs needed in the apparatus. When resumed 
on the 5th of June, the dog was in excellent health. Table XIII. p. 217, 
gives the results of observations during the administration of small and gra- 
dually increasing doses of corrosive sublimate. 
During the first three days 1 of a grain of corrosive sublimate was 
injected under the skin once a day. During the next six days the same 
quantity was injected twice a day, and on the tenth day (June 16) the dose 
was increased to 3 of a grain at the second injection. 
During these ten days the biliary secretion underwent marked variations ; 
the average daily quantity was 113-8 grammes of fluid bile, 5-972 grammes of 
bile solids, and 0-99 gramme of bile salts. These figures show that there was 
a slight diminution in the biliary secretion during this period. At the same 
time, however, the amount of food consumed had undergone a considerable 
decrease, but the health of the animal had not suffered, and its weight 
remained almost exactly the same. On June 17, the increased dose of 4 
of a grain twice a day was given. Athough these doses produced no pur- 
gation, foetid breath, or salivation, yet the dull eye and general drooping 
uneasy aspect of the animal showed that the general health was deci- 
dedly impaired. On that day (17th) there was a great decrease in the 
biliary secretion. The bile solids fell to about a third, and the fluid bile to 
about a fourth of what it had been on the previous day. The amount of 
food consumed, however, had been but slightly diminished, as compared 
with the previous day; but a glance at the Table wiil suffice to show that 
more food was consumed on the 17th than on the 11th, 13th, and 15th. On 
all these days at least thrice as much fluid bile, and about twice as much 
bile solids had been secreted. On June 18 only + of a grain was given ; 
and after the collection of bile on that day the observations were suspended, 
on account of the very marked impairment of the general health occasioned 
by the mercury. On that day the following is the note that was taken of 
the condition of the animal :—‘‘The dog looks miserable and lifeless, his 
_ health is evidently much impaired, there is no salivation, foetid breath, 
nasal discharge, or purgation.” The quantity of bile secreted on the 18th, 
though above that of the previous day, was nevertheless very low. The 
consumption of food had greatly diminished ; and it should be noticed that 
on the 10th the biliary secretion, instead of undergoing a still further dimi- 
nution, consequent on the decreased consumption of food, was, in fact, 
augmented. This, in our opinion, could only be attributed to the infuence 
of a smaller dose of the drug. 
The collection of the bile was in this case quite perfect on every day, 
with one exception (May 31), recorded in Table XII. The observations 
distinctly show that corrosive sublimate, given in small gradaally increasing 
doses, did not augment the biliary secretion. On the contrary, they point out 
