220 REPORT—1868. 
that so long as the general health remained good, the amount of bile was 
not changed, but as soon as the animal became weak, diminution of the 
secretion at once took place. 
Dog 8 was a strong mongrel collie, about five years old, weighing 19-3 
kilogrammes. The operation for biliary fistula was performed on the 2nd of 
June, 1868. The recovery was rapid, and observations, with a view to 
determine the normal secretion of bile, were commenced June 17th. The 
results are given in Table XIV. p. 217. 
The bile was perfectly collected for eight days. On one day (20th) the 
apparatus was not applied. When the observations were commenced, the 
animal was in perfect health, the feces were quite white and semisolid, 
On the 21st it had a slight attack of diarrhcea, which had, however, disap- 
peared on the following day. With this exception, the health of the animal 
was exceedingly good during the whole period, and instead of a loss there 
was a slight gain in weight. The diminution of the biliary secretion on 
the 21st cannot be ascribed to the diarrhea, seeing that on the next day, _ 
when it had ceased, a still greater decrease took place. The average daily 
amount of bile during the above period was, of fiuid bile 180-2 grammes, 
of bile solids 5:96 grammes, of bile salts 1- 07 gramme. The dog’s appetite 
was remarkably good. It was decided that corrosive sublimate should now 
be given in small and gradually increasing doses as in the previous case. 
Table XY. p. 219, gives the results. 
During the first eight days 1 of a grain of corrosive sublimate was 
given twice a day. On July 5th and 6th 2 of a grain were given in the 
day. On July 7th and 8th the dose was 3 of a grain twice a day. Until 
July 8th the animal continued in good health; then its appetite began 
to fail. 
The average amount of bile secreted daily during the twelve days from 
June 27th to July 8th inclusive was, of fluid bile 150-19 grammes, of bile 
solids 3-374 grammes, and of bile salts 1-135 gramme, During this period 
the amount of fluid bile was one-sixth less than during the premercurial 
period ; but the diminution in the bile solids was still more marked, the 
average quantity not being much more than a half of what was secreted 
during the premercurial period. This diminution was entirely due to a de- 
crease in the organic solids of the bile, indeed the amount of the inorganic 
solids was slightly increased. 
On July 9th two-thirds of a grain were given, as on the two previous 
days. The falling off in the appetite now became more marked, and the 
animal looked ill. There was a great failure in the biliary secretion; fluid 
and solid bile were reduced to about a half of what they had been on the 
previous day. One-third of a grain was given upon the following day 
(10th). ‘This was the last dose. Symptoms of seriously deteriorated health 
were very apparent some hours after it was given. The animal refused 
almost all food; it looked very languid; its breath was foetid; there was 
shght salivation, and on the mucous membrane inside the upper lip there 
was an incipient ulcer, which experience regarding the effects of mercurials 
on the mouths of other dogs enabled us to recognize as mercurial. The 
feeces, which previous to the administration of the mercury had been white, 
were during the greater period of exhibition sometimes white, at other times 
grey, and during the two last days of a slate-colour. There never was 
purgation. Latterly the animal became rapidly emaciated. Up to the 6th 
it maintained its weight well, but during the last four days it lost 3-49 kilo- 
