ON THE ACTION OF MERCURY ON THE BILIARY SECRETION. 227 
the first dose was given the fluid bile was 220-9 grammes, bile solids 10-42 
grammes ; on the following day the fluid bile was 154-5 grammes. After 
the second dose the fluid bile was 150 grammes, the bile solids 1-95 gramme. 
The next day (27th) no medicine was given, and the fluid bile rose to 297 
grammes, and the bile solids to 11-99 grammes, most conclusively showing 
that doses of podophylline which produce purgation diminish the fluid and 
solid constituents of the bile. 
Taste XIX.—Second Series of Observations on Dog 5. Daily amount of 
Bile secreted before, during, and after Podophylline and Taraxacum were 
given. 
2. 3 4 5 
Weight ¢ Quantity of bile 
of Amount of food, in SS ae in 24 
Date. dog. gr ee hours. Observations. 
Pann ; || Fluid! Bile | Bile 
Kilogs. || Water. | Milk.) Bread. Spleen.| ites: solide | celta 
-}. 1868. | grms. | grms. | grms. ‘ 
Aug. 23.)| 147 566 | 566 | 225°6 | 906°8 || 282°3/ 11:56] 3:0 || Dog in good health, though rather lean. 
| Feces semisolid. 
ee 74S Fe P 3 » || 2209] 10-42] 2-84|) Dog in good health, though rather lean. 
’ | Feces semisolid. 
see eH) a = = - 5 154°5| 4:20) 1°58 || 6 grains Resina Podophylli given 20 hours 
previous to the collection of bile. Pro- 
Fie purgation. 
» 26./) 146 rey 9 a * 150 1-95| 0°52|| 6 grains Resina Podophylli given 23 hours 
previous to this collection of bile. De- 
cided purgation. 
Pree (3 =e “= = = Me 297 11:99} 3:21|| No medicine given. 
n 28. aa a a ” 842-1 || 396 10:21| 2°42)| 60 grains solid extract of taraxacum given 
24 hours before this collection of bile. 
No purgation. 
eo: 14 “A rr x 906'8 || 340 9°36 | 2-12.| 60 grains solid extract of taraxacum given 
24 hours before this collection of bile. 
No purgation. ; 
nw” BO: fat a FF = id Lost. | .. ie No medicine given, 
SR OREH NS ho 3 Spa oie As Lost.| .. No medicine given. + 
Sept. 1. wee 4 _ 5 ~ ay | 317 9-42| 2-46 | No medicine given. 
sy 2: ve = 9 pe “2 355°5| 10°61} 3°02|| No medicine given. 
» 3.|| 14°38 Ps 9 re a 298 9°53 | 2°27|| No medicine given, 
Nore.—As the weight of the dog and the amount of food eaten by it were so constant in this case, we 
have not thought it necessary to calculate the amount of bile secreted per Kilogramme weight of dog, or 
per 100 grammes of food consumed. 
Observations with Extract of Taraxacum. 
After dog 5 had had a day’s rest from the action of podophylline, 60 
grains of solid extract of taraxacum were given 24 hours previous to the 
collection of bile on August 28th; on that day the fluid bile rose to the 
extent of 99 grammes, but the bile solids fell to the extent of 1:78 gramme. 
Next day the same dose was repeated; the fluid bile fell to the extent of 
56 grammes, the bile solids to the extent of 0-85 gramme. Neither dose 
produced any effect upon the bowels. After this no more medicine was 
given. The bile was unfortunately lost on August 30th and 31st, owing 
to slipping of the apparatus; on the three following days the amount of 
finid bile fluctuated greatly. On September 2nd it was 355-5 grammes,— 
a larger quantity than that secreted during the 24 hours after the second 
dose of the taraxacum was given; on that day also (September 2nd) the 
amount of bile solids secreted was greater than on either of the days on 
which taraxacum was given. It is therefore evident that the taraxacum 
did not increase the solid constituents of the bile; and it is extremely 
probable that the large amount of fluid bile secreted after the first dose was 
