306 REPORTS ON THE STATE OF SCIENCE. 
in relation to the power of six volumes CHCl,=450, gives as the 
anesthetic power of ACE compared with that of chloroform 166 : 450 
or 0°37. ; 
For a mixtue of two volumes chloroform with three volumes ether 
the similar value comes out as 165 : 375 or 0°44. 
I proceeded to test these values by the experimental determination 
of equitoxic concentration of mixtures in relation to the toxicity of 
pure chloroform. And although the determinations have not been as 
numerous as I could have wished, owing to the fact that I had to make 
them myself and that my time is limited, yet they have given results 
that have been near enough to show that the method is sound. 
Thus with 2°5 per 1000 solutions of the mixtures (2C+3E) and 
(1A+2C+8E) as compared with a 1 per 1000 solution of chloroform 
alone, I found that the first came out ‘ too strong ’ and the second * too 
weak.’ In terms of chloroform power taken as =1 the values of 
these two solutions —0'44 and 0°87, so that to make up their solutions 
to be equitoxic with a 1 per 1000 solution of chloroform I should have 
taken 2°3 and 2°7 c.c. per 1000 for the two solutions respectively. 
Considering that the excess and deficiency of 0°25 above and below 
these theoretical values 0°23 and 0°27 is only 0°02, and consider- 
ing further the tentative character of those theoretical values, this result 
must be adinitted to be very satisfactory. It affords further proof of 
the statement made above that the effect of mixed anesthetics is the 
sum of the effects of the individual components. 
For all practical purposes I think it sufficient to say that I find the 
physiological efficacy upon muscle of an ACE mixture and of a CK 
to be approximately equal to that of chloroform the ACE being slightly 
pp y eq a5 ) § Signtty 
weaker than the CE mixture. 
_ Effect of a 2°56 per 1000 solution (by volume) in normal saline of the following 
mixture: (1 volume alcohol + 2 volumes chloroform + 3 volumes ether), 
Effect of a 1 per 1000 solution (by volume) of chloroform in norma] saline, 
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