314 REPORTS ON THE STATE OF SCIENCE. 
During 80 minutes the animal had had injected into the circulation 
70 c.c. of chloroform saline (0°350 gramme of chloroform) and 60 c.c. 
of ether saline (3 grammes of ether). 
The effect of 0°5 gramme of ether was rather greater than that of 
0°05 gramme of chloroform. 
The effect of 04 gramme of ether was, as nearly as possible, equal 
to that of 0°05 gramme of chloroform—i.e., by weight chloroform was 
found to be about eight times as powerful as ether. We proceeded to 
compare the effects of chloroform and alcohol, taking ‘ chloroform 
saline ’ at 0°5 gramme per 100 of chloroform, and ‘ alcohol saline’ at 16 
grammes per 100 of ethyl alcohol. Our anticipation was that approxi- 
mately equal effects should be produced by the intravenous injection of 
equal volumes of these two solutions, and as a matter of fact our expec- 
tation was fulfilled by the following experiment :— 
Experiment No, 4.—August 3, 1909. Cat 2°5 kilos. 
Fall of 
Min. Blood-pressure, Blood-pressure. 
4 C, 150 50 
6 A, 150 50 
9 Cc 150 50 
13 IN 140 50 
18 C; 100 40 
22 E, (5 c.c.) 90 30 to 60 
32 A, 5 100 20 
42* C, 100 30 
45* A 90 30 
- 
In this experiment the depressions of blood-pressure by what we had 
taken as physiologically equivalent injections of chloroform and alcohol 
were practically equal; we noted, however, that the alcohol depression 
was more gradual and more enduring than the chloroform depression. 
The ether depression was characteristically double. 
Experiment No. 5.—August 5, 1909. Cat 4 kilos. 
Min. Blood-pressure. Fall. 
4 Chl, 8 c.c. 0:040 gm. 200 50 
6 Ale, 10 1:600 ,, 200 80 to 130 
13 Chl, 10 c.c. 0:050 ,, 150 20 
18 Ale, 5 c.,c. 0:800 ,, 150 10 
20 Chl, 10 0:050 ,, 150 30. 
Death. 
Experiment No. 6.—August 6,1909. Cat 1:3 hilos ; injections of 5 ¢.c. alcohol suline, 
ether saline, and chloroform saline. 
Fall of 
Time. Injecti Blood-pressure. Bloud-pressure. 
Min. mC Mm. Hg. Mm. Hg. 
3 A, 140 60 
25 E, 130 50 
45 C, 120 40 
50 A, 110 50 
60 AS 100 60 
70 E, 100 50 
80 Cc, 90 50 
Further experiments will be required to bring out in detail, by the 
method of saline injections, the comparative effects of chloroform, ether, 
and alcohol (and other reagents). The examples we have quoted may, 
however, be taken as preliminary evidence of the mutually confirmatory 
* See Plate XIII. ~ 
