ON ANESTHETICS. 277 



Experiment 5. — la which successively increasing amounts of CHC1 :! were given 

 from tested bags : — 



CHC1 3 2 per cent. 4 -0157 



3 „ 15 -0220 



3 15 £ -0370 



23 

 4-5 „ 23} 



32 -0399 



46 -0520 asphyxia. 



/■animal allowed to recover 

 OfiloJ partially, then killed by 

 air bubbled through 

 CHC1 3 . 



1 



Experiment 6. — Instance of a troublesome animal that kept ceasing to breathe 

 and had abnormal and varying type of respirations and unusual twitchings : — 



Time in CHCI3 per cent, 



min. of blood. 



CHCI3 2 per cent. 7 '0120 



26 -0220 



bags changed to 3 „ 41 '0310 (near asphyxial point). 



[animal brought round arti- 

 •0280 I ficially and killed by 4"5 

 [ per cent, in 11 minutes. 



Series of Data as to the Amount of Chloroform in the Blood at the Asphyxial 

 Point under Various Percentages of Chloroform Inspiredt 



1. Experiments in which asphyxia was rapidly reached — within 

 fifteen minutes, and before any equilibrium had been reached. ' Early 

 asphyxia ' : — 



Average of Inspired air, Mgms. of Limits in 



number chloroform per 100 gins. extreme 



of experiments per cent. of blood experiments 



7 3-4 48 25-63 



3 4-5 38 37-41 



2 5 40 40-41 



2. Experiments in which asphyxia occurred after equilibrium had 

 been established. ' Late asphyxia ' : — 



15 about 2 45 35-55 



7 3 62 42-61 



5 3 5 49 48-57 



3 4 53 44-68 

 2 4-5 59 41-77 



Prom the data given, which obviously are as yet insufficient to 

 warrant a precise conclusion, it is clear that the differences in experi- 

 ments as regards the chloroform percentage in inspired air are so great 

 that it is difficult to assign a value to the relation. Nevertheless, there 

 is on the whole at the asphyxial point an augmented percentage of 

 chloroform in blood with augmented percentage in inspired air. 



Without laying undue stress upon the results of individual experi- 

 ments, we may give the following diagram to illustrate the actual 

 percentages found in the blood of two different animals anaesthetised 

 by chloroform at between 3 and 4 per cent, and at" about 2 per cent. 



