534 REPORT—1905. 
Comparison of Gases in Blood from Renal Veins and Carotid Artery during 
periods of Rest and Diuresis. 
COMPARISON , ' ' I, Il. III. 
TIME , . a ° ‘ 1h. 52m. | 8h. 54m. 4h. 40m. | 
———— — A | 
5 [ied —_ z 4 . 
Arterial Venous | Arterial Venous | Arterial Venous 
— ——— ! = ~ ' 
Oxygen, per cent. . en I ye 7 23°6 20°2 165 22:2 176 | 
CO,, per cent. d 4 50.0 50°6 359 35:7 382 46:0 
—_—__-— SS --— ee — | 
O, exchange per min. . 0-9 cc. 4°3 c.c. 13° cc. | 
COnis et we “aa 0-9 cc. 1:9 c.c. 23 cc. | 
Urine per min. c | 0:02 c.c. 49 c.c. 0:18 c.c. | 
Work per min., CS 
lated from freezing- | | 
points | 
84 g.c.m. nil nil 
The call for oxygen depends upon the degree of diuresis, and not the 
rapidity of the blood-flow. In many experiments the diuresis has not 
been accompanied by any vascular augmentation, though it has always 
been accompanied by increased oxygen consumption. 
The carbonic-acid output of the kidney does not go hand in hand 
with the oxygen intake at any given moment, nor is the variation in 
the former at all so large as in the latter. Over a large number of 
experiments, however, the carbonic-acid output is approximately equal to 
the oxygen intake. Probably the want of apparent harmony between the 
oxygen absorbed and the CO, excreted is due largely to the solubility of 
the CO, in the tissues in which it is produced. 
The Pancreas.—The carbonic-acid output of the pancreas has claimed 
the attention of the Committee. A considerable number of experiments 
have been performed upon the resting pancreas, These may be divided 
into two classes :— 
Ist Class. In which the carbonic acid produced is approximately equal 
to the oxygen taken in. 
2nd Class. In which there is a negligible CO, production, with a 
normal oxygen intake. 
The 2nd class might be explained either by the supposition that only 
penultimate products are formed, or that the pancreas was consuming its 
own CO, in the formation of alkali to be subsequently secreted. The 
latter view seems the most probable on account of the following considera- 
tions : (a) The gland is taking up an ample supply of oxygen, hence there 
is no reason why oxidation should be incomplete. (6) As much as 
300 volumes per cent. of carbonic acid can be pumped from acidulated 
pancreatic juice (simultaneous titration shows that the alkali is present 
chiefly as sodium bicarbonate, but partly as sodium carbonate). 
The observations of 1904 indicating that flow of pancreatic juice is 
