636 REPORT— 1897. 



Plethysmographic observations on the blood-vessels of the limb^ spleen, 

 and kidney in this respect gave concordant results. 



IV. Effects of Deutero-Albumose. 



(a) On blood coagulation. — With regard to influence on blood-coagu- 

 lation, this substance has been found to produce a marked hastening in 

 certain of the experiments, while in others a marked retardation was 

 observed. Nor can the difference be .nttributed to the amount of dose. 

 So far this has proved irregular. 



Thus hastening has been obtained as follows : — 



Doae pel' kilo 



005 grm. 

 0-20 „ 

 0'20 „ 

 0-30 „ 



Dose per kilo 



0-075 grm. 

 01 

 01 

 0-1 

 0-2 



.„ A Ar [ Not after three hours. Coagu- 



" "'I lated next morning. 



In the first two of the latter group of experiments there is reason to 

 believe a somewhat overdose of curare had been administered, and also 

 that this substance produces an effect on blood-coagulation. A new 

 supply of this substance had just been obtained which proved to be very 

 active. In these two experiments, with dogs 9-4 and 8-5 kilos respectively, 

 the dose actually given was only two cubic centimetres of a 1-per-cent. 

 solution. 



Further experiments are in progress which it is hoped will throw 

 light on the want of uniformity in the eflects of the above doses. 



(b) On blood-pressure and vaso-motor irritability. — Ten experiments 

 were made in blood-pressure and recorded. The dogs varied in weight from 

 7 to 18-1 kilos, the doses employed being 0-2 grm. per kilo in four experi- 

 ments, 0-1 grm. in three, 0-3, 0-075, and 0-05 in one experiment each 

 respectively. 



The general conclusion arrived at is that this substance produces a 

 more profound and enduring influence on blood-pressure than pure 

 peptone, but less than the same dose of Witte's peptone. Deutero- 

 albumose cannot therefore be regarded as the most potent constituent of 

 "Witte's peptone. The experiments here recorded are in agreement with 

 those of other observers on this point. 



(c) On blood-vessels of the limb, kidney, and spleen respectively. — 

 Observations were made on the effect of deutero-albumose on limb blood- 

 vessels in two experiments, using Mosso's plethysmograph ; on those of the 

 kidney also in two, employing Roy's apparatus ; and on those of the 

 spleen in four, with the modified Schafer's spleen-box. 



The results showed that the vaso-motor mechanism of these organs 



'O" 



