722 



REPORT — 1898. 

 Table l.—confinved. 



Exp. 



Hour 1 



Hour 2 



I j Weight 



Hour 3 Hour 4 Hour 5 of Dog 



I in kilos. 



Quantity of 



Fluid 



injected 



VI. Anti-jjeptone. 



61 



10 



22 



38 



78 



fSOm.iO-J 



[ 10m.S-5 



[ 43m..22-3 



50 c.c. 

 40 „ 

 40 „ 

 SO „ 

 50 „ 



30 „ 

 25 „ 



The figures in italic in the column for the second hour sliow the amount of urine 

 passed in the number of minutes indicated. The same applies, mutatis vivtandis, to 

 the subsequent tables. 



No marked difference -svas manifested by the various substances in 

 regard to the amount of diuresis produced, e.x;cept that the proportion of 

 instances where no increase of urine manifested itself was decidedly 

 greatest in the case of the substance anti-peptone. 



It is doubtful, however, if any stress can be laid upon diuretic influences, 

 since control experiments made by injecting corresponding quantities of 

 normal saline solution, without peptone or albumose, showed that a 

 marked increase of urine, also reaching its maximum in the second hour 

 afterwards, was produced by the solvent employed. This is illustrated 

 in the following table : — 



Table II. — Showing the Influence of Normcd Salt Solution upon the 



Quantity of Urine secreted (expressed in cubic centimetres). 



(The injection was made at the end of the first hour, and extended over a period of 



4 to 8 minutes.) 



* In Experiment No. 1 an injection of 12 c.c. of caustic soda solution, 0*2% 

 strength, was made at tlie end of the third hour. 



The above effect, produced by small quantities of normal salt solution 

 when introduced into the circulation, has proved to be a matter of very 

 considerable interest, and forms the subject of a different research, which 

 has arisen out of the present one. 



Some observations were made on the reaction of the urine passed 

 before and after the injection of the proteid. The majority of cases 

 showed the normal urine to be alkaline. This alkaline was reduced to 

 neutrality in the second or third hours or both, and gradually returned to a 

 weakly alkaline condition, for the most part, before the close of the fifth hour. 



