726 



REPORT — 1898 



The marked increase in the hourly output of total nitrogen and of 

 urea, beyond that contributed by the proteid injected, cannot, however, 

 be solely attributed to any influence which the substances employed 

 might be supposed to exert upon nitrogenous metabolism. A similar 

 though less marked influence is shown after the injection of normal salt 

 solution alone. This is expressed in the following table, where it will be 

 observed that the maximum efiect is likewise shown in the second hour : — 



Table VI. — Showing the Effects of Normal Salt Solution on the Nitrogen 

 excreted Hour hy Hour (exjjressed in Grammes). 



(N.B. — The injection of normal saline was made at the end of the first hour.) 



Exp. No. 



1* 



2 



3 



4 



5 



6 



7 



Hour 1 



•1115 

 •1050 

 •1570 

 •1754 

 •3497 

 •2481 

 Nitrog' 



Hour 2 



•0956 

 •1204 

 •2082 

 •3021 

 •5533 

 •3181 

 en not de 



Hours 



Hour 4 



•0857 



•2066 

 •2489 

 •3748 

 •2378 

 termined 



•0551 



•0923 

 ■2113 

 •2583 

 •2677 



Hour 5 



•0767 



•1120 

 •2074 

 •2285 



•2482 



Weight 



of 



Dog 



6^7 

 6-4 

 16-8 

 15 

 14-9 

 19-5 

 14-8 



Quantity 

 injected 

 per kilo. 



4 



4 



3 



2 



35 



2-5 



3 



CO. 



Total 

 quantity 

 injected 



28 CO. 



26 „ 



50 „ 



30 „ 



50 „ 



50 „ 



45 .. 



* In Experiment No. 1, an injection of 12 c.c. of caustic soda solution, 0-2 per cent, 

 strength, was made at the end of the third hour. A mixture of morphine and atropine 

 was employed by mistake to inject this dog. 



Observations upon body temperature, taken per rectum, showed that a 

 steady rise occurred after the injection was made. The rise generally 

 appeared towards the end of the first hour after injecting, and for the most 

 part continued to increase till the end of the experiment. 



Thus, in Experiment XXI. (proto-albumose) the temperatures were as 

 follows : — Normal 37-4°C. ; at end of first hour 37° C — the injection was then 

 made ; at the end of the second hour, temperature 37° C. ; at the end of 

 the third 37 ^8; at end of fourth 38° C. This was not the highest tempera- 

 ture attained by any means; the maximum in several experiments reached 

 40° C, and in one it reached 41-2° C. 



This rise of temperature occurred even when the fluid injected was 

 previously sterilised by boiling, and notwithstanding precautions to keep 

 the animals cool while on the table. A similar rise of temperature also 

 took place when sterilised normal salt solution was injected. In some of 

 the experiments the maximum temperature was attained in the third hour 

 (second after injection), followed by a return towards normal in the subse- 

 quent hours. 



III. Amount of Peptone or Alhumose excreted in the Urine. 



This was regarded as an important point to determine. It bears upon 

 the question as to whether the substances under observation are to be con- 

 sidered as wholly foreign to the blood, or to be looked upon in the same 

 light as dextrose, which is excreted by the kidneys only when the amount 

 in circulation exceeds a certain point. 



Previous experimenters had arrived at diflferent conclusions with regard 



