FURTHER STUDIES OF SOLUTION TENSION AND 



TOXICITY IN LIPOLYSIS^ 



Raymond H. Pond 



This paper is really a continuation of an earlier one' which supplied 

 data showing that the toxicity of certain salts in lipolysis does not vary 



decomposi 

 disagrees with that of :Mathews 3 McGu 



As my conclu- 



and as Berg and Gies^ found that the nature of the zymolyte is an 

 important factor in peptolysis and tryptolysis, it seemed desirable to 

 determine whether the same general relation found by me for the tox- 

 icity of several nitrates in the lipolysis of ethyl butyrate would also hold 

 m the case of some other ester. Ethyl acetate was selected as the 

 2ymoI}te because its saponification is a monomolccular reaction, 

 because acetic acid is a close homologue of butyric acid, and because 

 LoEVENHART and Peirce^ found that the hydrolysis of ethyl acetate 

 IS inhibited to a greater extent by sodium fluorid than that of ethyl 

 butyrate. They also expressed the \^ew that the inhibiting effect of 

 sodium fluorid is dependent upon the acid radical from which the 

 ester is derived, while the alcohol arising in the saponification is a 

 comparatively indifferent factor. 



Since the same general procedure has been foUowed here as in the 

 preceding investigation, many of the details given before will be omitted 



^ From the laboratories of the New York Botanical Garden. 



Ph ' T"^^^' R-'^^'iiOND H., Solution tension and toxicity in lipolysis. Amer. Jour. 



ysiologj' 19:258-283. 1907. Contributions from the Xew York Botanical Gar- 

 den 94. 



eh V ^™^.^^' •^- ^•' The relation between solution tension, atomic volume, and 

 tne physiological action of the elements. Amer. Tour. Physiolog^- io:290-3-'3- ^904- 



salts 

 1904- 



il r elements. Amer. Jour. Physiolog>- 10:290-323. 1904- 



■ d y^^'^^' ^^^^ ^I-' The relation between the decomposition tension of 

 an their antifermentative properties. Amer. Jour. Physiologv io:444-4Si- 



The 



Box. 



409-419 



6 BzaG, W. X., and Gies, Wm. J., Studies of the effects of ions on catalysis, «-ith 

 ar reference to peptolysis and trv-r>tr,IW« T^,,. -r;,.! r-^^r^ -,- ,Sr^ci6. ioP7- 



Jour. Biol. Chem. 2:489-546- i^7 



on the »^' ''T';^^' "" ^■' ^""'^ Peirce, Geo., The iahibiting effect of sodium fluorid 

 on tue action of lipase Tour m^.] r-u 



R«f-.:..t ^ _ .J ■' ^^' ^^^^- 2:379-413- 1907- 



Botanical Gazette 



