270 
author has calculated 22 additional numbers. He also had 
proved that if » were a prime number other than 2 or 3, 
the numerator of the » in Bernoulli's number was divisible 
by n. 
Professor CAYLEY called attention to one or two points con- 
nected with the paper. 
Mr GLAISHER said he had observed that in dividing 
B, B, 
3 and 3" 
the period of all the circulation was ‘the same; he had verified 
this for about 28; he had not yet proved it, but conceived it 
would follow from Clausen’s theorem. 
(2) On some of the symptoms produced by Uremic por- 
soning in chronic disease of the kidney. By P. W. 
Latuam, M.D. 
The object of this paper was to shew that many of the 
symptoms, as to the mode of production of which in chronic 
Bright’s disease much discussion has hitherto arisen, might rea- 
sonably be explained. That the factors involved were :— 
(1) The impeded passage of the blood through the minute 
arteries of the system, caused by excessive contrac- 
tion and hypertrophy of the muscular walls of these 
vessels, as has been demonstrated by Dr George 
Johnson. 
(2) The hypertrophy of the heart, developed by the re- 
sistance offered to the circulation from the contrac- 
tion of these small arteries; and 
- (8) The impoverished state of the blood, which is the 
necessary accompaniment of the disease. 
