402 
Tt was remarked that the results of this investigation make 
it appear, that the true law of underground temperature would 
be better obtained from borings of moderate than of very great 
~ depth, because the disturbance of the temperature curve from 
the rectilinear form is greater the further we descend. 
April 19, 18757. 
THE PResIDENT (PROFESSOR BABINGTON) in the Chair. 
On the Physiological Action of Jaborandi. By 
Mr J. N. Lanaury. 
[ Abstract.] 
The preparations used are 
(1) The alcoholic extract of the crushed Jaborandi leaves. 
(2) The glycerine solution of this extract evaporated to 
dryness. , 
The results of experiments point to there being more than 
one active principle. 
Injected subcutaneously there is one striking difference in 
the action of Jaborandi on the Frog and the Rat. In the 
former it causes convulsive movements with occasional tetanic 
spasms, in the latter it acts as a narcotic. Death in one case 
is probably more immediately caused by the stopping of the 
heart's beat ; in the other by paralysis of the respiratory centre. 
eine cheer rog convulsive movements are noticeable if any 
part of the spinal cord be left intact, but not otherwise. 
Reflex action is greatly depressed. 
Jaborandi has little or no effect on nerves, their endings in 
striated muscle, or on striated muscle itself. 
If an arterial blood-pressure tracing be taken of a ieee, 
and Jaborandi injected into a vein, it causes 
; (1) A fall in the blood-pressure. 
(2) A slowing of the pulse. 
(3) Generally a flattening of the respiratory curves, 
? Omitted, by accident, from the last Number of the « Proceedings.” 
