404 
heart of a frog which has ceased beating may be caused to beat 
again by putting a few drops of dilute solution of Atropin on it. 
As the heart regains its rapidity of beat, the inhibitory 
power of the pneumogastric is lost. 
Since the slowing takes place after a large dose of Curari, it 
probably acts more peripherally than the endings of the vagus 
nerves. 
Some curves obtained after a dose of Jaborandi very 
strongly suggest that they are due, not to the ordinary effects 
supposed to give the respiratory curves, but to a rhythmic 
increase in the force of the heart-beat. 
Some tracings show a want of correspondence between the 
‘respiratory curves’ of the blood-pressure and the respirations : 
it is hoped that further inquiry into this and some other devia- 
tions from the normal tracings may throw some further light on 
the causes of the rhythmic variations in blood-pressure. 
(3) The flattening of the respiratory curve is probably very 
largely, if not entirely, a mechanical effect of the slowing of the 
heart-beat; a like flattening is obtained by a weak stimulation 
of the pneumogastric. 
Whether Jaborandi, apart from the alcohol or glycerine. in 
which it is dissolved, can produce a local stasis, is doubtful but 
not impossible. 
Jaborandi causes in Mammals at first a quickening of the 
respiration, then a slowing, then a paralysis of the respiratory — 
centre: in one rabbit (under chloral) in which respiration had 
been stopped by a slow injection of J. aborandi, it was restored 
after two or three minutes of artificial respiration. 
With regard to the effect on the secretions, only a few 
experiments have been made more than mentioned in a Pre- 
liminary Notice last February. In Mammals the lachrymal 
and salivary secretion are always increased, but in no case has 
it been observed to cause sugar in the urine, 
