ON THE PHYSIOLOGICAL EFFECTS OF PEPTONE. 607 
vascular dilatation in the splanchnic region, the chief accumulation of 
blood seems to take place in the liver, exceeding even that in the vessels 
of the intestine. 
(d) The vessels of this district, owing to their easy dilatability, pro- 
bably play the part of a safety receptacle to the heart, thereby guarding 
it against over-influx of blood under conditions of great dilatation in the 
splanchnic vascular territory. 
(e) The substances examined produce a great depression of vaso- 
mobility in the liver district, the vessels of this organ thus showing a 
high degree of susceptibility to the influence of the bodies here employed. 
(f) The different substances show the same order of potency in their 
influence on the liver district as is manifested by them elsewhere. 
5, Limb Vessels. 
(a) Some influence is undoubtedly exerted on limb vessels by the pro- 
ducts here dealt with, but this influence is very slight, less even than in 
the case of renal vessels. 
(6) Little or no dilatation is experienced by these vessels during the 
period of fall of general blood-pressure. 
(c) Here, also, the influence of the primary proteoses is greater than 
that of the other bodies examined. Indeed, the former may be said to be 
the only members of the group which possess any influence on limb 
vessels. 
From the foregoing local vascular manifestations, the following con- 
clusions of a more general nature may be deduced : 
1. That the blood-vessels of different vascular districts show different 
degrees of susceptibility to ‘peptone’ influence, and play unequal parts in 
producing the general results which follow an injection of peptone or 
proteoses. 
2. The vessels of the splenic, intestinal, and hepatic districts constitute 
a group eminently sensitive to ‘peptone’ influence, while those of the 
kidney and limbs are eminently insensitive in this respect. 
3. Amongst the vessels of the first group, those of the splenic district 
are least susceptible, those of the liver most so, while those of the intes- 
tine occupy an intermediate position. 
Section V. Hffects on Urinary Secretion. 
Work in this section was also brought to a temporary completion, and 
furnished interesting and important deductions. An article dealing with 
these will shortly be published. The results attained invite further inves- 
tigation, which it is intended to take in hand during the coming year. 
Part of the work of completion just alluded to involved the perform- 
ance of a series of control experiments to determine the influence which 
the anesthetic employed might exert on the secretion of urine. These 
showed that the peptone effects were in no wise modified by the influence 
of the anesthetic. 
Section VI. Lffects of Antipeptone-constituents. 
Tt has recently been shown that antipeptone is composed of a number 
of different bodies, the chief amongst these being Arginin, Histidin, and 
Lysin. It was therefore deemed advisable to extend the research into an 
