158 Mr Adami, On the disturbances of temperature [Mar. 9, 



(1120° F.) or more, in one case becoming as much as 45'325° C 

 (113'58° F.). Removal of the cotton wool checked the rise and 

 often induced an actual fall through more than a degree in the 

 course of two hours. With an atmosphere slightly warmer 

 (24° C) no cotton wool was necessary to bring about an ascent. 

 Transference to a room whose temperature was some degrees 

 below 22° C led to a rapid lowering of the point to which the 

 mercury rose. Thus in one case, the fowl being placed in a room 

 at 24° C. and covered with wool, the body temperature rose four 

 degrees in five hours, from 40*2° to 44'2° C. ; transferred to a room 

 at 18° the animal shewed in less than three hours a fall through 

 5*6 degrees, to 38'6° ; then replaced in the room at 24°, this time 

 without a covering of wool, the temperature rose slowly but 

 steadily until it reached 42 - 8° at the end of eight hours. I might 

 adduce many other instances to the same effect. 



Similarly, in animals whose fore-brain had been extirpated, 

 15 ccm. of cold water poured into the crop caused a fall of from 

 half a degree to a degree during the course of the succeeding 

 half-hour. This amount of cold water has no effect upon the 

 body temperature of the normal fowl. On the other hand a rich 

 proteid diet in the form of an egg, beaten up and warmed to 

 nearly the temperature of the body, caused invariably a well- 

 marked rise of one to three degrees beginning two to three 

 hours after the animal had been fed. This rise reached its 

 maximum in about six hours, and may be compared to the rise 

 that has been found to occur in the crocodile and, I believe, 

 the snake, after a large meal of animal food. 



It may be noted here that while change to a cooler atmosphere 

 caused lowering of the body temperature, this lowering, if the 

 change had not been too considerable, tended to give place 

 eventually to a slow rise. To this extent the reaction differs 

 from what obtains in the cold-blooded animal, and despite the 

 removal of the fore-brain there would seem to be a tendency for 

 the body temperature to be brought back to the normal. 



With the temperature liable to such great and constant 

 fluctuations it was extremely difficult to determine the effects 

 of injections of fever-producing substances, as, for example, 

 sterilised bouillon in which the Vibrio Metschnikovi had been 

 grown, or to know at what moment these might be made. Never- 

 theless in the two cases in which such injections were performed 

 under what appeared to be favourable conditions there was so im- 

 mediate and steady a rise of temperature through two degrees 

 during the succeeding eight hours, that I am led to see in this 

 rise an indication that febrile changes may be induced in the 

 hen deprived of its hemispheres, and, if it be accepted that in 

 the fore-brain lies the main heat regulating mechanism of the 



