1882.] Leucine and Glycocine into Urea. 183 



Again, if propene cyanamide is brought into contact with any of 

 the urethanes, we shall have in a similar manner the amide of 

 glutamic acid produced — 



co I NH ° + r h l NH ph ho 4. r h f NH - c O NH * 



C0 l0CH 3 + C » H «l0N = CH 3- H 0+C 3 H 6 | CN 



urethane propene cyanamide cyanide 



or = CH 3 .HO + C 3 H 5 (NH 2 ){^ (NH2)V 

 cyanide 



CH^jW + 2H.0 . Cj H. (NH,) {° ™ * ™. 



amide of glutamic acid 



Lastly, and most interesting of all is the combination which 

 would appear to result if the urethane is brought in contact with 

 HCN instead of NH 3 . By condensation and combination of three 

 molecules the formula again indicates the liberation of the corre- 

 sponding alcohol with the formation of uric acid and cyanamide — 



3CO loCH +3HCN= 3CH 3 .HO + 5 H 4 N 4 O 3 + CN.NH 2 



methyl alcohol uric acid cyanamide 



the cyanamide combining with water to form urea — 



rNH, 



CN.NH, + H,0 = CO 



NH 



cyanamide urea 



Similarly for pentyl urethane we have 



3C0J™; T + 3HCN= 3C 6 H u .HO + C 5 H 4 N 4 3 + CN.NH 2 



lOb 5 K u 



isopentyl urethane amyl alcohol uric acid cyanamide 



Having shown that if a urethane is produced from an amido-acid 

 these other changes may follow, I will now endeavour to point out 

 how the transformation is possibly effected. 



* See note on opposite page. 



