150 Mr Marshall, Note on cannabis resin. [April 27, 



occurred, especially at first, and sometimes the muscles of my face 

 were drawn to an almost painful degree. The most peculiar effect 

 was a complete loss of time relation : time seemed to have no 

 existence. I was constantly taking out my watch thinking that 

 hours must have passed, whereas only a few minutes had elapsed. 

 This I believe was due to a complete loss of memory for recent 

 events. The occurrence of lucid intervals was also peculiar in 

 many ways. They seemed to come on suddenly, sometimes, but 

 not always, as if the result of an effort of the will ; they lasted a 

 variable time, beiag shortest when the symptoms of intoxication 

 were most marked ; and in them I could converse in a rational 

 manner and even direct the work of the laboratory to a certain 

 extent. Except in a few instances I do not remember falling 

 under the full influence of the drug again. About 6 o'clock I had 

 two cups of coffee and afterwards feeling somewhat better walked 

 home. The fresh air and exertion revived me. I ate a good 

 dinner, afterwards read a little, and retired to bed at 11 o'clock 

 without having experienced any symptoms of sleepiness. 



During the action of the cannabinol my pulse rose from 60 to 96 

 per minute ; sensibility as determined by pinching was blunted ; 

 and my appearance was described as " ashy pale." The pupils 

 were dilated somewhat, but throughout reacted well to light and 

 accommodation. At no time do I remember having had any hallu- 

 cinations ; no unpleasant after-effects were experienced ; and the 

 substance seems to possess no constipating action. 



Smaller doses produced similar though less marked effects ; 

 with doses of less than *01 g. no distinct action was obtained. 



Monday, 11 May, 1896. 

 Professor J. J. Thomson, President, in the Chair. 



The following communications were made to the Society : 



(1) Note on the formation of the germinal layers in Amphioxus. 

 By E. W. Mac Bride, M.A., Fellow of St John's College. 



The account of the early development of Amphioxus incor- 

 porated in text-books is due to Hatschek (" Studien fiber die 

 Entwicklung des Amphioxus," Arb. Zool. Inst. Wien, 1881). Briefly 

 summarized it is as follows : the segmentation of the egg results 

 in the formation of a regular blastula, which becomes converted 

 into a gastrula by regular embolic invagination. The mesoblast 



