66 



SECTIONAL ADDRESSES 



A number of variants on tetraamyldiaminodecane were then made in 

 whi<:;h in the place of the symmetrical tetraamyl group various other 

 combinations were tried, with the results shown in the following table. 



A number of compounds were then prepared in order to test the 

 amcebicidal properties of related classes of compounds. 



(i) Long chain monamines. 



(2) Quaternary benzylammonium chlorides containing a long chain 

 member, since members of this class have been shown by the 

 LG. Farbenindustrie A.G. to have marked bactericidal properties, 

 and quaternary salts of the corresponding diamines. 



(3) Long chain mono- and di-amidines. 



(4) Compounds in which the 10 aliphatic carbon atoms of decane are 

 replaced in part by 4 carbon atoms of a benzene ring, and in part 

 by 2 atoms of oxygen. 



None of these approached tetraamyldiaminodecane in amcebicidal 

 efficiency in vitro, as will be seen from the individual results given below : 



Approxitnate amcebicidal efficiency 

 in comparison with T.A.D.D. 



Per Cent. 



. ID 



Not 10 

 . 25 



Compound. 



Group I. 



Hexadecylamine ..... 



' Octon ' (methylamino-6-methyl-2-heptene-2) 

 Dibutylnonylamine . ... 



^ All radicles are of the normal series except where stated otherwise. 



