348 SECTIONAL TRANSACTIONS.— B. 



malonaniloethylamide j)-arsonate (I : n = i ; Rj = H ; R2 = Et), sodium 

 succinanilomethylamide p-arsonate (I : n = 2 ; Ri = H ; R2 = Me), and 

 sodium glutaranilodimiethylamide ^-arsenate (I : w = 3 ; Ri = Me ; 

 R2 = Me) were chosen for further trials on rabbits. Of these three com- 

 pounds the succinyl derivative, now known as Neocryl, was eventually 

 selected for clinical trial. 



Prof. Warrington Yorke and collaborators in the Liverpool School of 

 Tropical Medicine have reported favourably on the action of Neocryl in 

 all stages of syphilis, and Lester, working in Nigeria, has also obtained good 

 results in the treatment of sleeping sickness. 



Neocryl is now being tested on a larger scale under the auspices of the 

 Therapeutic Trials Committee, but it is still too early to give a final judg- 

 ment on the value of the drug. 



Dr. W. KiKUTH. — Experimental chemotherapy of malaria. 



The great successes in the chemotherapy of malaria which have been 

 achieved within recent years are due to team-work by chemists and bio- 

 logists. Earlier attempts to treat malaria more efficiently by chemical 

 means failed because no suitable test existed. It was not until bird-malaria 

 (Proteosoma preecox), which proved so useful in the elucidation of many 

 malarial problems, had been adopted for biological tests that the chemo- 

 therapy of malaria received a fresh stimulus which led to the discovery of 

 the first synthetic remedy for malaria, plasmoquine. In contrast to quinine, 

 plasmoquine possesses the property of destroying the sexual forms of 

 malaria ; it is, however, almost ineffective against the asexual forms of the 

 parasites. A further advance in the biological test was made by employing 

 rice-finches infected with hcemoproteus . Owing to this improvement it 

 was possible to differentiate in the laboratory between the effect of plasmo- 

 quine and that of quinine, and to discover a preparation which acts in the 

 same manner as quinine, viz. atebrin. Further refinement of the method 

 of testing as regards its specificity will result in new progress in the therapy 

 of malaria. 



Prof. R. Robinson, F.R.S. 



Afternoon. 



Excursion to Boots Pure Drug Company, Ltd., Island Street, Not- 

 tingham. 



Friday, September 3. 



Symposium on Protein chemistry (lo.o). 



Prof. C. R. Harington, F.R.S. — The contribution of organic chemistry 

 to the problem of protein structure. 



The historical development of the peptide theory of protein structure is 

 outlined and the main lines of experimental evidence upon which it is 

 based are discussed. 



The importance of peptide synthesis for the study of proteins is emphasised 

 and the earlier methods are briefly reviewed. The recently developed 

 carbobenzyloxy method of Bergmann is treated in detail and its applica- 



