44 JVarcotine, and Sulphate of Morphine. 



That narcotic, nervine, and stimulant operations, as here defined, 

 are perfectly distinct operations, is abundantly proved, by the fact 

 that there are numerous articles, which possess each individually, 

 without any trace of the others ; and the circumstance that two of 

 these groups of effects, or even the whole three, are not unfrequently 

 produced by the same articles, no more proves their identity, than 

 the circumstance that Tobacco is both narcotic and cathartic, proves 

 that these two effects are identical. 



RESULTS OF EXPERIMENTS WITH NARCOTINE. 



1st. In the same quantities, Narcotine is far less operative upon 

 the human system, than the Sulphate of Morphine, and even less 

 so than Opium. 



2d. Narcotine possesses the same degree of activity, when given 

 pure and in substance, as in any other way tried, its virtues not being 

 either enhanced or diminished by solution in oil, or in dilute Acetic 

 acid. 



3d. From two to five grains of Narcotine appears to constitute 

 a medium full dose, where only a single dose is to be taken, i. e. 

 such a dose as will just fall short of producing any disagreeable ef- 

 fects, in a person of ordinary susceptibility. 



4th. One grain of Narcotine appears to constitute a medium 

 moderate dose, to be repeated at regular and short intervals; — and 

 three hours appear to constitute a medium suitable period of repeti- 

 tion for such a dose, for a person of ordinary susceptibility. 



5th. Narcotine is slower, though it is less permanent in its ef- 

 fects, than the Sulphate of Morphine. The period required for 

 the first manifestation of the several effects of Narcotine, is inter- 

 mediate between that required for the effects of Sulphate of Mor- 

 phine, and that required for the effects of Opium ; and the period of 

 their duration is intermediate between that of the effects of Opium, 

 and that of the effects of Sulphate of Morphine.* 



6th. Narcotine appears to be more or less nervine. The general 

 nervine operation of Narcotine, I think is decidedly less than that 

 produced by Sulphate of Morphine, but I am not certain that it is 

 less than that of Opium. Nai-cotine does not appear to produce any 



" It is remarkable that Morphine, whicli is much more speedy in its operation, 

 appears to be more permanent in its effects even than Opium. 



