26 Mr Noon, Therapeutic Inoculation for 



Conclusion. 



The presence of a generalised bacterial infection is not an 

 efficient stimulus to call forth the best protective reaction of which 

 an experimental animal is capable. 



Description of Figures, 



Fig. 1. Curve I, mean of opsonic indices of three guinea-pigs 

 which survived infection more than 12 days (one recovered). 



Curve II, mean of indices of six guinea-pigs which survived from 

 6 to 10 days. 



Curve III, index of guinea-pig which survived 5 days. 



(a) Date on which all the guinea-pigs were infected with equal 

 small doses of B. pseudotuberculosis, intraperitoneally. 



(6) One guinea-pig died. 



(c) Four died. 



\d) Two died. 



The first dot of each curve represents two separate estimations of 

 the index of each guinea-pig. 



Fig. 2. Continuous line, composite curve of opsonic indices of 

 nine rabbits which were infected with living bacilli on day 1. 



(a) Three of these animals died. 



Interrupted line, composite curve of indices of five rabbits, inocula- 

 ted with killed bacilli on day 1. 



Fig. 3. Agglutinating power of rabbits of Fig. 2, 

 Continuous line, diseased rabbits (three animals). 

 Interrupted line, inoculated animals. 



The numbers at the bottom refer to the same days as those in 

 Fig. 2. 



Fig. 4. Opsonic index of rabbit which received a subcutaneous 

 dose of 250 million killed bacilli per kilogramme of body weight on the 

 14th day of the disease (a). 



The dots represent independent estimations, the curve is drawn 

 through the mean of each pair of estimations. 



Fig. 5. Opsonic index of a diseased rabbit which received a sub- 

 cutaneous dose of 5000 million killed bacilli per kilogramme of body 

 weight. Pairs of independent estimations. 



Fig. 6. Opsonic index of the rabbit of Fig. 5, after receiving a 

 subcutaneous dose of 500 million killed bacilli per kilogramme of body 

 weight (a). Pairs of independent estimations. 



