SCIENCE— ADVERTISEMENTS 



Danysz and Rackemann-THE EVOLUTION OF DISEASE '""/IeT 



With a Discussion of the Immune Reactions Occurring in Infectious 

 AND Non-infectious Diseases. A Theory of Immunity, of Anaphylaxis and 

 of Antianaphylaxis. 



Professor Danysz has clearly and logically traced the various stages in the 

 development of acute infectious diseases; and developed an interesting 

 theory of the evolution of chronic morbid states whose etiology and patho- 

 genicity are today so little understood and whose treatment is therefore as 

 difficult as it is unsatisfactory. The book should be of interest to those who 

 recognize the importance of a comprehension of the principles underlying 

 the study and treatment of disease. 

 The secondary consequences in the organism of the conditions of immunity 

 and anaphylaxis, which result from recovery in infectious disease, or from an 

 habitual or periodical digestion of antigens are discussed in Part II. 



The study of these questions has led to the conclusion that all the chronic 

 morbid states with their periods of acute crises alternating with longer or shorter 

 remissions, originate from antigens, and are determined by the state of immunity- 

 anaphylaxis of the organism. The necessary experimental confirmation of 

 this hypothesis has shown in reality that the anti-anaphylactic treatment is of 

 unquestionable efficacy in all those chronic diseases in which we have been able 

 to apply it up to date (except organic mental diseases) and a long series of ob- 

 servations corroborates this. These results have been obtained by non-specific 

 antigens. 



The work is concluded by a general theory of immunity, anaphylaxis and 

 anti-anaphylaxis, based on the structure, properties and function of the organism, 

 and of the structural and functional units comprising it. 

 CONDENSED CONTENTS 

 PART I: — The Theories of Immunity (Metchnikoff and Ehrlich). Experimental Researches 

 Inspired by these Theories. — Physicochemical Properties. Transformation of the Arsenobenzenes 

 "In Vitro" and in the Organism. {Relations between Apparent Toxicity and Formation of Precipitates. 

 Reactions of the Organism. Formation of a Specific Antibody, etc.) — Evolution of the Infectious Diseases. 

 (Diphtheria, Tuberculosis, Typhoid and Paratyphoid Fevers, Cholera.) — Mechanism of Infection. In- 

 fection or Contagion. Virulence, Immunity, Refractory State. (Origin of the Affinities between the 

 Antigens and the Normal Antibodies. Immunity and Reciprocal Anaphylaxis of Infecting Bacteria and 

 of Infected Organisms, Etc.) — Immunity and Anaphylaxis. (Reason for the Existence of Anaphylaxis. 

 Nature of the Antigens, Colloids. Action and Nature of Antibodies, Etc.) — Influence of the Central 

 Nervous System on Immunizing Reactions and on Anaphylaxis. (Action of Hypnotic and Anesthetic 

 Agents on Anaphylactic Shock. Action of Violent Emotions on the Metabolism of the Suprarenal Capsules, 

 Etc.)- — Therapeutic Measures. (Latent Anaphylaxis. Actual Anaphylaxis. Specificity of Antigens 

 in their Vaccinating and Curative Action. Preventive and Curative Action of Non-specific Antigens, 

 Skepto- or Tachyphylaxis. Anti-anaphylatoxins. Uniformity of Reactions in Anaphylactic and Anaphyla- 

 toxic Crises. Chemotherapy, Bacteriotherapy, Serum Therapy.) — Principles of the Classification of 

 Infectious Diseases. — General Conclusions. 



PART II: — Evolution of Theories Concerning Immunity, Anaphylaxis and Anti-Anaphylaxis. 

 (Researches by Pasteur, Roux and Yersin, Behring and Kitasato Transfusion of Blood and Infection of 

 Heterologous and Homologous Sera and Other Proteins. Physiological and Physicochemical Causes of the 

 Formation of Antibodies in Excess by Antigenic Action. Immediate and Secondary Results of the Condi- 

 tions of Immunity-anaphylaxis. Origin of Chronic Non-contagious Diseases, Etc.) — Principles of the 

 Anti- Anaphylactic Treatment of Chronic Diseases by Entero-Antigens. (Case Reports. A. Dermatoses. 

 B. Asthma. C. Other Cases. Summary of Observations. General and Local Reactions Caused in the 

 Organism by Entero-antigens. Theory of Curative Reactions. Kendall's Experiment. The Influence of 

 the Nervous System.) — General Summary: Theoretical Deductions. (Theory of Immunity, of Anaphylaxis 

 and of Anti-anaphylaxis.) 



By Professor J. Danysz, Chief of Service, Pasteur Institute, Paris. Translated by Francis M. 

 Rackemann, M.D., Assistant in Medicine in the Harvard Medical School and in the Massachusetts 

 General Hospital. i2mo. 194 pages. Cloth, $2.30 net. 



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