OCTOBBK 15, 1920] 



SCIENCE 



369 



described by McAlpine^ for Ophioholus grami- 

 nis. Peritbicia in considerable abundance 

 were found embedded in the leaf sheatli and 

 mycelial plate. Microscopic measurements of 

 peritbecia and ascospores 'agree very closely 

 witb tliose given by Saccardo for Ophioholus 

 graminis. 



As soon as a determination of tbe fungus 

 bad been made steps were taken to determine 

 tbe source of tbe infection and to completely 

 eradicate tbe disease from tbe infected area. 

 An inspection was made of tbe farm wbieb bad 

 grown tbe seed for tbe past two years. No evi- 

 dence of take-all was found on tbis farm or on 

 any of a considerable number of otbers in tbe 

 vicinity of tbe diseased field and elsewbere. 

 The crop from an area forty feet in diameter 

 was spread over tbe ground and gasoline was 

 poured over tbe infected spot and vicinity. 

 Tbe whole was tben burned over. 



Tbe writers are indebted to Dr. W. B. 

 Brierly, of tbe Eotbamsted Experiment Sta- 

 tion, England, and Professor Et. Foex, of tbe 

 Station de Patbologie Vegetale, Paris, France, 

 for examination of tbe affected wheat. Dr. 

 Brierly states that tbe disease is indistinguish- 

 able from tbe take-all as it occurs in England. 

 Professor Poex concludes that tbe associated 

 fungus is undoubtedly a species of Ophioholus. 

 Saccardo lists two species of Ophioholus as 

 occurring on wheat, 0. graminis Sacc. and 

 0. herpotrichus (Er) Sacc. The ascospores 

 of 0. herpotrichus measure 135—150 X 2-2.5 

 microns, practically double tbe spore length of 

 0. graminis. It has already been pointed out 

 that tbe fungus under consideration agrees 

 closely in spore measurements with Saccardo's 

 0. graminis. It is not intended here to settle 

 tbe question of tbe pathogenicity of tbe Ophio- 

 holus as it occurs in tbis country or abroad. 

 However, both tbe fungus and tbe diseased 

 symptoms with' which it is associated agree in 

 essential details with tbe take-all of wheat and 

 Ophioholus graminis as described in Australia, 

 France and elsewhere. E. S. Kirby, 



H. E. Thomas 



Cornell trNrvEEsirr 



2 MeAlpine, D., ' ' Take-all and WMte Heads in 

 Wieat," Victoria Dept. Agr. Bui, 9, 1904. 



THE AMERICAN CHEMICAL SOCIETY. 

 XII 



DmSION OF PHARMACEUTICAL CHEMISTRY 



Charles E. Caspar!, chairman 

 Edgar B. Carter, secretary 

 Staiility and cMoramine antiseptics: Jules 

 Bebie. 



Chemistry and pharmacology of the cTiloramines : 

 Carl Nielsen. 



Colorimetric estimation of adrenalin: Wilbur 



L. SCOVILLE. 



Improved methods for arsenic estimation: H. F. 

 Farr. 



The melting point and the determination of free 

 salicylic acid in acetyl salicylie acid: L. A. Watt. 



Biological methods for digitalis assay: Herbert 

 C. Hamilton. 



Besearches on hypnotics: E. H. Volwiler. 



Besearches on anesthetics: Eoger Adams. 



Wood alcohol and prohiiition: Chas. Basker- 

 ville. 



Drug absorption in the intestinal tract: G. H. 

 A. Clowes and A. L. Walters. 



Iodine telerance of the human hody and iodine 

 therapy: H. C. P. Weber. A very unusual case of 

 cure of tubercular meningitis is discussed. Only 

 isolated instances of recovery from this disease are 

 known in the literature. The cure was effected by 

 dosage with extr'aordinary quantities of iodine, 

 given as tincture with various albuminoses and 

 fatty vehicles of administration. The maximum 

 was 1 gram of iodine per day (equivalent to 0.033 

 g. per kg. body weight) ; the total equaled 12.35 g. 

 over 22 consecutive days. No iodism was noted. 

 The conclusions drawn were that (a) the maxi- 

 mum dose of I is not known, (6) the disturbing 

 effeclts, iodism, are astonishingly small, or even 

 absent, (c) therapeutic effects as bactericide, re- 

 quire piling up of I in the body, {d) that the dis- 

 turbing effects of KI are often confused with the 

 effects of I itself, (e) that aside from this, the 

 methods of administering the I are of less signifi- 

 cance. These conclusions seem to be worthy of, 

 and require, verification. 



The pharmaceutical chemistry and pharmacol- 

 ogy of the chloramines: Carl Nielsen. To ob- 

 tain best results with the chloramines some knowl- 

 edge of the chemistry of these products, partic- 

 ularly as regards incompatibilities, combinations 

 and pharmacologic action, is essential. 



Besearch on hypnotics: E. H. Volwiler. His- 

 tory of hypnotics, soporifices, and sedatives. 



