386 
At slightly above its melting point dibromhydrin 
dissociates completely into two molecules, hydro- 
bromic acid and probably epibromhydrin. 
Pure 1, 2-dilaurin, diisovalerin and diacetin have 
been ebtained. 
R. R. RensHaw: Investigation of Choline and its 
Derwatives. (Third paper.) 
By the action of phosphorus oxychloride on 
choline chloride there has been obtained a highly 
hydroscopic, unstable chlorcholine phosphorie acid 
dichloride. 
Experiments on the stability of choline salts 
have been carried out both by physiological and 
chemical tests. Pure choline salts give a lowering 
of the blood pressure. Choline chloride is not a 
very unstable salt. It can be preserved without 
decomposition into trimethyl amine or neurine. 
WiLuiaM J. Hate: The Formation of Nitropyri- 
midines. 
Cuas. H. HERtTy and C. S. VENABLE: The Schkate- 
loff Method for Reduction and Precipitation of 
Resin Acids. 
CaRL O. JOHNS: On 2-Oxy-1-Methylpurine. 
The potassium salt of 2-oxy-5-nitro-6-aminopyri- 
midine was heated with methyl iodide and a mono- 
methyl derivative was obtained. The position of 
the methyl group was ascertained by converting 
this compound into 2, 6-dioxy-3-methyl-5-nitropyri- 
midine. When 2-oxy-3-methyl-5-nitro-6-aminopyri- 
midine was reduced with ferrous hydroxide it gave 
2-oxy-3-methyl-5, 6-diaminopyrimidine, which in 
turn gave a formyl derivative the potassium salt 
of which, when heated, formed the potassium salt 
of 1-methyl-2-oxypurine. The free base crystal- 
lized with 2 molecules of water. The picrate 
decomposed at 214° C. 
CarL O. JOHNS: 
Methylpurine. 
2-Oxy-5, 6-diaminopyrimidine was heated with 
formie acid and a monoformyl derivative was pro- 
duced. The potassium salt of this compound 
liberated water when heated and the potassium salt 
of 2-oxypurine was produced. The free base erys- 
tallized with one molecule of water and the crys- 
tals were stable at 110° C., but the water escaped 
at 130° C. The picrate decomposed at 245° C. 
Acetic anhydride reacted with 2-oxy-5, 6-diamino- 
pyrimidine and the chief product was a mono- 
acetyl derivative. The potassium salt of this was 
heated and the potassium salt of 2-oxy-8-methyl- 
purine was obtained. The nitrate decomposed 
violently at 205° C. and the picrate at 250° C. 
On 2-Oxypurine and 2-Oxy-8- 
SCIENCE 
[N.S. Vou. XXXV. No. 897 
M. L. Crosstey: A New Derivatwe of Anthroqui- 
none. 
M. T. Bocrrt and M. HEIDELBERGER: Phthalones 
m the 4-Quinazolone Group. 
2-Methyl-4-quinazolone condenses smoothly with 
phthalic anhydride to the symmetrical phthalone, 
which behaves as a weak acid, forming a yellow 
mono-sodium salt and a red disodium salt, as well 
as a red mon-anil, a mono-phenylhydrazone and a 
sulfonie acid. Energetic reduction converts the 
phthalone into the corresponding hydrindone. 
Bromination of the sulfonic acid of the phthalone 
in aqueous solution yields a dibrom 2-methyl-4- 
quinazolone, which is not the 6, 8-dibrom compound, 
a pentabrom 2-methyl-4-quinazolone, a monobrom 
2-methyl-4-quinazolone sulfonie acid, phthalic and 
sulfuric acids. An interesting feature of the reac- 
tion is that the bromine splits the phthalic acid 
off from the quinazolone. 
6-Nitro and 7-acetamino 2-methyl-4-quinazolone 
condense similarly to phthalones. With phthal- 
imide, the 2-methyl-4-quinazolone condenses to the 
unsymmetrical, or beta, phthaline, with formation 
of a small amount of what appears to be a bis- 
quinazolone phthaline. 
2-Methyl-4-quinazolone and succinic anhydride 
react vigorously with production of a tarry mass, 
from which a colorless anhydro body may be 
isolated. 
2-Methyl-4-quinazolones carrying alkyl groups in 
position 3 either refuse to condense with phthalic 
anhydride or give but small yields of phthalone. 
In none of the experiments was the formation 
of any isophthalone observed, nor could we isolate 
any intermediate products except the phthalate of 
the quinazolone. 
Like the quinophthalones, these phthalones act 
as yellow dyestuffs, but in tinctorial power they 
seem inferior to the former. 
M. T. Bogert and G. A. GEIGER: On Certain New 
Quinazolines. 
The following new 4-quinazolones have been iso- 
lated and studied: 3-ethyl; 3-benzyl; 2-methyl-3- 
p-nitrophenyl; 2-methyl-3-p-tolyl; 2-methyl-3-alpha 
naphthyl; 2-methyl-3-beta naphthyl; 6-nitro; 6- 
amino; 6-acetamino; 6-nitro-3-methyl; 6-amino-3- 
methyl; 6-acetamino-3-methyl; 6-nitro-3-ethyl; 6- 
amino-2, 3-dimethyl; 6-nitro-2-methyl-3-ethyl; 6- 
amino-2-methyl-3-ethyl; monobrom and brom-2- 
methyl. j 
The 3-methyl-4-quinazolone of Knape (mp. 
71°) carries a molecule of water of crystallization, 
the pure anhydrous substance melting at 105°. 
