1919. | The Sixth Indian Science Congress. ]xxxv 
in my work I cannot speak too highly of, all the more important 
points of my cholera cases, now amounting to just over 2,000, 
and have closely studied the records of all fatal ones to ascer- 
tain the reasons for the failures with a view to findin 
of lessening them. The following examples will illustrate some 
of the results thus obtained. 
After an experience of a year and a half of the hypertonic 
treatment, I realized that something more was required if the 
mortality was to be still further reduced. The failures ap- 
eared to me to be largely due to a recurrence of the collapse on 
account of absorption of the toxins produced by the cholera 
bacillus in the intestinal canal with the restoration of the cir- 
culation after the saline injections. Now the toxins are con- 
testinal antiseptics may very possibly add to the toxin ab- 
sorption by killing the bacilli, which is, I believe, one of the 
reasons for their failure as already stated. I therefore sought 
for some method of destroying the toxins themselves while still 
unabsorbed in the bowel, and, bearing in mind that they are 
largely albumoses and other unstable albuminous products of 
the metabolism of the organisms, and that such substances are 
readily destroyed or rendered inert by oxidizatio ri- 
mented with various oxidizing agents, and particularly with 
ermanganates, whic wn to rapidly destroy in 
previously worked. I was thus able to demonstrate that several 
times a lethal dose of dead comma bacilli containing the toxins 
of course it cannot by itself save the most severe cases with 
extreme collapse 
ALKALIES IN THE PREVENTION OF FataL RENAL CoMPLI- 
CATIONS. 
There still remained one very important line of investiga- 
tion, which has recently led to a further substantial reduction 
