cexiv Proceedings of the Asiatic Society of Bengal. [N.S., XV, 
(6) phonons brs pathological changes are caused by therapeutic 
dos uinine—(a) in health, (b) in cachectic states. 
The ats of malaria by quinine. —By Masor-GEnERAL 
HEHIR 
tent to which quinine is curative of malaria has only recently 
The 
been investigate ed and recorded scientifically. Careful malarial work has 
been i ess at home during the war, and ica Dagshai Malarial 
Depot i is carrying out similar work in India. The results of this i inquiry, 
it is hoped, will anh some definite ie n regarding the minimum 
ose of quititins necessary to Urkaibate the dis 
The Dagshai Malarial Depot was opene ed i Ms ee il, Ges for the treat- 
ment of 2 ish Troop end ef ne com- 
modation was available for 45 cases i és now 1 000 ¢ used. 
The cm dt of this ry for the period ending the 30th of Mind inesatg 
1918, h 
ai the mased conditions are very favourable for the treat- 
ent of chronic malaria for there are n pheline mosquitoes ther me 
reinfections are eliminated. gations have b concentrate 
the tre ent o ic malaria, especially the prevention of re pses se 
soo administration of various quinine salts given in diffe igen ov in 
arying quantities. i : a ses except two were chroni 
infections ies ich h i quinine. Inv 
nic benign 
resisted estigations were seientifialy 
arried out, well controled, and carefully recorded. No case was treated 
till the parasite und, 
The 
ahldidg Niuhiods were tried at Dagshai ;—- 
ConTINUOUS. ORAL ADMINISTRATION OF 2 marae: SULPHATE. 
(a) In doses from 15 to 30 grains daily for 
ut of 73 cases Rervages 34 Valngaca Mb aes 
i eks eiieand by 15 grains 
or 90 dave Out of 93 cases ixiated 7 ie ate within 5 
(c) In owes of 30 grains daily for 8 weeks. Out of 91 cases II 
lapsed within 5 weeks. 
INTERMITTENT ORAL ADMINISTRATION. 
(a) 45 al on two consecutive days bai for 8 weeks, Out of 
s 32 relapsed within 3 we is method was more 
Engl 
and as details of pare aealis carried out by 
Professor Stevens show 
Out of 110 cases pain retehtce gine during shaw 
ment. It is remarkable me this mK rg ould be m 
n the same quantity dg daily for 8 asia. 
e most successful method t: 
Stevens reports two Leg 5 = Gpiml - = gla nd on similar lines pe 
using huge doses ha grains). Ino his experiments 62% did n 
relapse within 60 days. Ina sedond. 04% relapsed in from 12 to 53 day 
the discrepancy is not explained. 
INTRAVENOUS INsEOCTIONS. 
The groups of cases treated with intravenous injections are too 
to give any reliable results, but as far as t 
venous trea 
or th 
on account of the rapidity with which the drug 
: : ; with the parasite, it is useful in pernicious 
t be reserved for intense and dang ean MANE RON 
